Objective: To explore the value of color Doppler ultrasound combined with VTIQ in evaluating the mobility of the wrist synovial membrane in rheumatoid arthritis. Methods: Sixty-four RA patients (64 wrist joints in total) were selected as the research objects, and they were divided into active group and remission group based on DAS28 score. CDFI and VTIQ were performed on the wrist joints of the two groups of patients, and the CDFI blood flow classification and SWV parameters (SWVmax, SWVmin, SWVmeanSWVstd) were obtained, and the differences between the two groups were compared. Draw the ROC curve of the synovial membrane, and compare the diagnostic efficiency of each parameter of SWV on the activity of the synovial membrane with AUC. Kappa test was used to compare the evaluation value of CDFI, VTIQ and the combination of the two on synovial activity. Results: Among the 64 wrist synoviums, there were 35 in the active group and 29 in the remission group. The CDFI blood flow classification and SWV parameters of the wrist in the active group were higher than those in the remission group, and the difference was statistically significant (P<0.05). ROC curve analysis found that SWVmean has the best diagnostic performance for evaluating synovial activity among the various parameters of SWV. When the cut-off value is 4.140m/s, SWVmean has the sensitivity, specificity, accuracy, positive predictive value and positive predictive value for diagnosing synovial activity. The negative predictive values ??were 74.28%, 89.29%, 79.68%, 89.65% and 73.52%, respectively. CDFI, VTIQ and the combination of the two have good consistency in synovial activity evaluation (Kappa values ??are 0.561, 0.628 and 0.718 respectively), and the combined application of the two has significantly higher diagnostic sensitivity, accuracy, negative predictive value and Kappa value In a single method (P<0.05). Conclusion: Both CDFI and VTIQ can be used to assess synovial activity in rheumatoid arthritis, and the combined application of the two has a higher diagnostic value.