| 摘要: |
| 目的 采用Meta分析方法评价超声造影检查联合穿刺活检诊断乳腺癌前哨淋巴结的临床效能。方法 系统制定文献检索方法以及筛选文献原则，中文检索主题词为超声造影、乳腺穿刺、穿刺活检、穿刺细胞学检查、乳腺癌、前哨淋巴结、转移在中文数据库中国知网（CNKI）、万方、中国生物医学文献数据库（CBM）、维普（VIP）、龙源期刊、医学库、国研数据库检索；英文检索主题词为Contrast Ultrasound、Breast cancer、Needle biopsy、Sentinel lymph node metastasis、Sentinel Lymph node biopsy在外文数据库PubMed、Embase、NEJM医学期刊、Cochrane图书馆检索；选出发表时间在2021年6月31日前关于穿刺活检结合超声造影诊断乳腺癌前哨淋巴结转移的有关文献，完成Meta分析。结果 按照筛选标准共检索纳入6篇中文文献，6篇英文文献，研究对象共计1645例，研究显示乳腺癌患者SLN无明显规律；合并统计量分别为合并SEN=0.685（95%CI：0.55~0.80）、合并SPE=1.000（95%CI：0.99~1.00）、合并SCC=0.903（95%CI：0.68~0.95）、合并诊断比值比=258.29（95%CI：97.82~721.58）、合并阳性预测值=1.000（95%CI：0.98~1.00）、合并阴性预测值=0.93（95%CI：0.87~0.98）。结论 超声造影引导下进行穿刺活检结果为阳性乳腺癌患者可直接行腋窝淋巴结清扫术治疗，阴性者则仍需考虑结合SLNB诊断以制定治疗方案。 |
| 关键词: 超声造影 乳腺穿刺活检 乳腺癌 前哨淋巴结转移 Meta分析 |
| DOI： |
| 投稿时间：2021-08-13修订日期：2021-10-26 |
| 基金项目: |
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| A meta-analysis of ultrasonography combined with aspiration biopsy for the diagnosis of anterior lymph nodes in breast cancer |
| peishengxin,zhang zhong,pengyulan |
| (West China Hospital，Sichuan University) |
| Abstract: |
| Objective To evaluate the clinical efficacy of ultrasonography combined with puncture biopsy for the diagnosis of anterior lymph nodes in breast cancer using Meta-analysis. Methods Systematic development of literature search methods and principles of literature screening, Chinese search subject terms for ultrasonography, breast puncture, puncture biopsy, puncture cytology examination, breast cancer, anterior lymph node metastasis in Chinese databases China Knowledge Network (CNKI), Wanfang, China Biomedical Literature Database (CBM), Vipers (VIP), Longyuan Journal, Medical Library, National Research Database; English search Subject terms were Contrast Ultrasound, Breast cancer, Needle biopsy, Sentinel lymph node metastasis, Sentinel Lymph node biopsy in foreign language databases PubMed, Embase, NEJM medical journal, Cochrane Library; literature related to puncture biopsy combined with ultrasonography for the diagnosis of anterior lymph node metastasis of breast cancer published before June 31, 2021 was selected and Meta-analysis was completed. Results A total of 6 Chinese literature and 6 English literature were retrieved and included according to the screening criteria, with a total of 1645 study subjects, which showed no significant pattern of SLN in breast cancer patients; the combined statistics were combined SEN=0.685 (95% CI: 0.55-0.80), combined SPE=1.000 (95% CI: 0.99-1.00), combined SCC= 0.903 (95% CI: 0.68 to 0.95), combined diagnostic ratio = 258.29 (95% CI: 97.82 to 721.58), combined positive predictive value = 1.000 (95% CI: 0.98 to 1.00), combined negative predictive value = 0.93 (95% CI: 0.87 to 0.98). Conclusion Patients with positive breast cancer by ultrasonography-guided mammocentesis can be treated directly with axillary lymph node dissection, while negative patients still need to be considered in combination with SLNB diagnosis to develop a treatment plan. |
| Key words: Ultrasonography breast puncture biopsy breast cancer anterior lymph node metastasis Meta-analysis. |
