Objective: To explore the relationship between ultrasound elastography and serum intercellular adhesion molecule-1 (ICAM-1), soluble intercellular adhesion molecule-1 (sICAM-1), Ki-67 positive expression rate, clinical stage and other clinical parameters in plasma cell mastitis Application in the evaluation of patient prognosis. Methods: The clinical data of 85 patients with plasma cell mastitis were selected for retrospective analysis. The selection time was from February 2018 to May 2020. According to the treatment effect, they were divided into a good prognosis group (n=67) and a poor prognosis group (n =18), compare the elastic strain rate and elastography score, analyze the clinical stage, Ki-67 expression, the correlation between ICAM-1, sICAM-1 and the elastic strain rate, elastography score, and evaluate the elastic strain rate and elastography Score, ICAM-1, sICAM-1 predict poor prognosis AUC, sensitivity, specificity and Youden index of PCM patients.Results: There was a statistically significant difference between the two groups in the comparison of nipple status, clinical stage, Ki-67 expression, ICAM-1 and sICAM-1 (P<0.05). The elastic strain rate and elastography score of the poor prognosis group were higher than those of the good prognosis group (P<0.05). Spearman correlation showed that clinical staging was negatively correlated with elastic strain rate (r=-0.219, P＜0.05), Ki-67 expression was positively correlated with elastography score (r=0.322, P＜0.05); Pearson correlation showed that, ICAM-1 and sICAM-1 were positively correlated with elastic strain rate (r=0.811/0.828, P＜0.05), and ICAM-1 and sICAM-1 were positively correlated with elastography score (r=0.782/0.850, P＜0.05). ROC curve analysis showed that elastic strain rate, elastography score, ICAM-1, sICAM-1, and AUC predicting poor prognosis of PCM patients were (0.926, 0.983, 0.955, 0.964, P<0.05).Conclusion: Ultrasound elastography, ICAM-1, sICAM-1 and other clinical parameters have high clinical value for evaluating the prognosis of PCM patients, and can provide guidance for clinical diagnosis and treatment.