| 摘要: |
| 目的：探讨超声弹性成像技术与血清细胞间黏附分子-1(ICAM-1)、可溶性细胞间黏附分子-1(sICAM-1)、Ki-67阳性表达率、临床分期等临床参数在浆细胞性乳腺炎患者预后评估中的应用。方法：选取85例浆细胞性乳腺炎患者的临床资料进行回顾性分析,选取时间为2018年2月至2020年5月,根据治疗后效果分为预后良好组(n=67)与预后不良组(n=18),对比弹性应变率、弹性成像评分,分析临床分期、Ki-67表达情况、ICAM-1、sICAM-1与弹性应变率、弹性成像评分的相关性,以及评估弹性应变率、弹性成像评分、ICAM-1、sICAM-1预测PCM患者预后不良的AUC、敏感度、特异性及约登指数。结果：两组在乳头状况、临床分期、Ki-67表达、ICAM-1、sICAM-1比较中,差异存在统计学意义(P＜0.05)。预后不良组的弹性应变率、弹性成像评分高于预后良好组(P＜0.05)。Spearman相关性显示,临床分期与弹性应变率呈负相关(r=-0.219,P＜0.05),Ki-67表达与弹性成像评分呈正相关(r=0.322,P＜0.05)；Pearson相关性显示,ICAM-1、sICAM-1与弹性应变率呈正相关(r=0.811/0.828,P＜0.05),ICAM-1、sICAM-1与弹性成像评分呈正相关(r=0.782/0.850,P＜0.05)。ROC曲线分析显示,弹性应变率、弹性成像评分、ICAM-1、sICAM-1、预测PCM患者预后不良的AUC分别为(0.926、0.983、0.955、0.964,P＜0.05)。结论：超声弹性成像与ICAM-1、sICAM-1等临床参数用于评估PCM患者预后具有较高的临床价值,能为临床诊治提供指导。 |
| 关键词: 浆细胞性乳腺炎 弹性成像评分 弹性应变率 ICAM-1 sICAM-1 Ki-67 |
| DOI： |
| 投稿时间：2021-09-03修订日期：2021-09-15 |
| 基金项目: |
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| Study on the value of ultrasound elastography and clinical parameters such as ICAM-1 and sICAM-1 in the prognostic evaluation of plasma cell mastitis |
| Mao Qianmei,Dong Jianlan,Su Tong,Li Danqiong |
| () |
| Abstract: |
| Objective: To explore the relationship between ultrasound elastography and serum intercellular adhesion molecule-1 (ICAM-1), soluble intercellular adhesion molecule-1 (sICAM-1), Ki-67 positive expression rate, clinical stage and other clinical parameters in plasma cell mastitis Application in the evaluation of patient prognosis. Methods: The clinical data of 85 patients with plasma cell mastitis were selected for retrospective analysis. The selection time was from February 2018 to May 2020. According to the treatment effect, they were divided into a good prognosis group (n=67) and a poor prognosis group (n =18), compare the elastic strain rate and elastography score, analyze the clinical stage, Ki-67 expression, the correlation between ICAM-1, sICAM-1 and the elastic strain rate, elastography score, and evaluate the elastic strain rate and elastography Score, ICAM-1, sICAM-1 predict poor prognosis AUC, sensitivity, specificity and Youden index of PCM patients.Results: There was a statistically significant difference between the two groups in the comparison of nipple status, clinical stage, Ki-67 expression, ICAM-1 and sICAM-1 (P<0.05). The elastic strain rate and elastography score of the poor prognosis group were higher than those of the good prognosis group (P<0.05). Spearman correlation showed that clinical staging was negatively correlated with elastic strain rate (r=-0.219, P＜0.05), Ki-67 expression was positively correlated with elastography score (r=0.322, P＜0.05); Pearson correlation showed that, ICAM-1 and sICAM-1 were positively correlated with elastic strain rate (r=0.811/0.828, P＜0.05), and ICAM-1 and sICAM-1 were positively correlated with elastography score (r=0.782/0.850, P＜0.05). ROC curve analysis showed that elastic strain rate, elastography score, ICAM-1, sICAM-1, and AUC predicting poor prognosis of PCM patients were (0.926, 0.983, 0.955, 0.964, P<0.05).Conclusion: Ultrasound elastography, ICAM-1, sICAM-1 and other clinical parameters have high clinical value for evaluating the prognosis of PCM patients, and can provide guidance for clinical diagnosis and treatment. |
| Key words: Plasma cell mastitis elastography score elastic strain rate ICAM-1 sICAM-1 Ki-67 |
