| 摘要: |
| 恶性肿瘤是全球发病率和死亡率的一个重要原因,严重威胁人类的健康。作为其常规的治疗方法,化疗、放疗和手术仍有局限性。自杀基因疗法为各种形式的恶性肿瘤提供了一种极具前景的治疗手段。超声靶向微泡破坏(UTMD)技术为自杀基因的传递赋予了新的方式。本文着重就 UTMD 介导的自杀基因转染在恶性肿瘤治疗中的最新进展进行总结并对其未来发展提出展望。 |
| 关键词: 超声靶向微泡破坏技术 自杀基因 微泡载体 恶性肿瘤 |
| DOI： |
| 投稿时间：2021-11-25修订日期：2021-12-13 |
| 基金项目:国家自然科学基金(81801712) |
|
| Research Progress of Ultrasound Targeted Microbubble Destruction Technology Mediated Suicide Genes in Malignant Tumors |
| wutong,huangchi,duzhaolin,yaoyiran,liuzhijun |
| () |
| Abstract: |
| Malignant neoplasm is an important cause of morbidity and mortality worldwide, which poses a serious threat to human health. As its conventional treatment methods, chemotherapy, radiotherapy and surgery still have limitations. Suicide gene therapy offers a highly promising treatment for various forms of malignancy. The ultrasound targeted microbubble destruction technology (UTMD) provides a new way for suicide gene delivery. This article focuses on summarizing the latest progress of UTMD-mediated suicide gene transfection in the treatment of malignant tumors and presenting prospects for its future development. |
| Key words: Ultrasound targeted microbubble destruction suicide genes Microbubble carrier Malignant tumor |
