| 摘要: |
| 特发性肺纤维化（idiopathic pulmonary fibrosis,IPF）是一种慢性进行性发展的致死性疾病，其特征是纤维化组织在肺实质内异常积聚，该病的患病率和病死率逐年增加，预后极差[1]。研究表明，血清中的血清涎液化糖链抗原-6(Krebsvonden Lungen-6，KL6)和基质金属蛋白酶-7 ( Matrix metalloproteinase 7， MMP7)是评估IPF进展的重要标记物[2、3]。肺部超声近年来也被广泛的用于肺纤维化的研究。然而，目前对于肺部超声评分与KL6及MMP7水平的相关性研究较少。先前我们团队经临床实践证实改良肺部超声评分法可用于评估肺间质疾病的严重程度[4、5]，但不甚清楚此改良法是否可反映肺纤维化的严重程度。本文旨在研究改良肺部超声评分法与肺纤维化程度及其血清KL6及MMP7相关性，为临床评估肺纤维化提供参考。 |
| 关键词: 肺纤维化 改良肺部超声评分 血清标记物 |
| DOI： |
| 投稿时间：2021-11-27修订日期：2022-01-04 |
| 基金项目:泉州市高层次人才计划项目(No.2018C071R)；泉州市科技计划项目(2018Z168) |
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| Evaluation of Pulmonary Fibrosis by Modified Lung Ultrasound Combined with Serum Markers |
| Lin Peihuang,huangyijun,Lyu Guorong,Kangzhuo,Xu Wu |
| () |
| Abstract: |
| 【Abstract】Objective To investigate whether modified pulmonary ultrasonography combined with serum salivary liquefaction carbohydrate antigen-6 (KL6) and matrix metalloproteinase-7 (MMP7) is helpful in evaluating pulmonary fibrosis. Methods: Thirty 3.0 ~ 4.0 kg male New Zealand white rabbits were randomly divided into experimental group (n = 15) and control group (n = 15). The rabbit model of pulmonary fibrosis was established by intratracheal injection of bleomycin hydrochloride in the experimental group, and the same amount of saline was perfused in the control group. After modeling, 5 animals in the experimental group and 5 animals in the control group were randomly selected for lung ultrasound scanning and determination of the contents of serum KL6 and MMP7 on days 14, 21, and 42, respectively, and sacrificed for pathological examination. The correlation between modified lung ultrasound scoring method, serum KL6 and MMP7 and pulmonary fibrosis was analyzed. Results ①Compared with the control group, there were significant differences in the modified pulmonary ultrasound score, lung histopathological score and serum Kl6 and MMP7 expression in the experimental group (P < 0.05), which increased with time. ②There was a strong positive correlation between modified lung ultrasound score, rabbit serum Kl6 level and MMP7 level and pathological tissue score (r = 0.925, 0.892, 0.808, respectively, P < 0.05). There was a strong positive correlation between the modified lung ultrasound score and serum Kl6 and MMP7 levels in rabbits (r = 0.884, 0.831, respectively, P < 0.05 for all). Conclusion The modified lung ultrasound scoring method combined with serum kl6 and MMP7 detection may be helpful for the assessment of the severity of pulmonary interstitial fibrosis. |
| Key words: Pulmonary fibrosis modified lung ultrasound score serum markers |
