摘要: |
目的:研究孕中晚期正常妊娠胎儿肾上腺下动脉(IAA)血流动力学参数,确定正常参考值范围。方法:从接受常规产前超声检查的18~36周孕妇中选取符合条件的604名进入研究,应用脉冲多普勒在双肾斜冠状切面测量胎儿IAA收缩期峰值流速(PSV)、舒张末期流速(EDV)和搏动指数(PI)、阻力指数(RI),建立其与孕周(GA)相关的正常参考值范围。用Pearson相关分析检验IAA血流动力学参数与孕周间相关性,将各参数与GA分别绘制散点图,拟合多种回归模型,选出最佳拟合曲线。结果:最终纳入594例胎儿。IAA的阻力参数(PI、RI)与孕周呈负相关(P均<0.05,r=-0.73,0.81),且均以Cubic曲线拟合度最佳。IAA的速度参数PSV与孕周无统计学意义(P>0.05),EDV与孕周轻度正相关(P<0.05,r=0.24),二者均以Cubic曲线拟合度最佳。结论:本研究建立了正常胎儿IAA血流参数的正常参考值范围,有助于进一步评估胎儿血流动力学。 |
关键词: 正常胎儿 肾上腺下动脉 阻力参数 速度参数 脉冲多普勒 |
DOI: |
投稿时间:2021-12-10修订日期:2022-01-20 |
基金项目:国家自然科学基金项目(面上项目,重点项目,重大项目)1.81501497产前三维超声联合功能磁共振、MicroRNAs研究先心病胎儿脑发育异常与损伤 2.81871372产前超声联合磁共振、IncRNAs评估母体氧疗干预先心病胎儿神经系统发育障碍的研究 |
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Reference range of blood flow parameters in fetal inferior adrenal artery during the second and third trimester of gestation |
zhuziling,zengshi,xuran,tangwenjuan,jinying,liuyushan |
(THE SECOND XIANGYA HOSPITAL OF CENTRAL SOUTH UNIVERSITY) |
Abstract: |
Objective:To study the blood flow parameters in fetal inferior adrenal artery during the middle and late trimester of normal pregnancy and to determine the normal reference range . Methods: A total of 604 pregnant women from 18 to 36 weeks who received routine prenatal ultrasonography were enrolled in this study. Fetal IAA peak systolic velocity (PSV), end-diastolic velocity (EDV), pulse index (PI) and resistance index (RI) were measured by pulse Doppler in oblique coronal section of both kidneys.The normal reference range related to GA was established. Pearson correlation analysis was used to test the correlation between IAA hemodynamic parameters and gestational age. Scatter plots were drawn for each parameter and GA, and various regression models were fitted to select the best fitting curve. Results: Finally, 594 fetuses were included. The resistance parameters of IAA (PI, RI) were negatively correlated with gestational weeks (P < 0.05,r=-0.73,0.81), and the Cubic curve was the best fit. There was no significant correlation between the speed parameter PSV of IAA and gestational weeks (P > 0.05). There was a slight positive correlation between), EDV and gestational weeks (P < 0.05,r=0.24). The fitting degree of Cubic curve was the best. Conlusion: This study established a normal reference range of normal fetal IAA blood flow parameters, which is helpful to further evaluate fetal hemodynamics. |
Key words: Normal fetus inferior adrenal artery resistance parameter velocity parameter pulse Doppler |