Objective: To explore the evaluation value of echocardiography combined with glycohemoglobin (HbA1c) and myeloid peroxidase (MOP) detection on the risk of myocardial injury in sepsis. Methods:A retrospective analysis of 88 patients with sepsis admitted to the ICU ward of our hospital from December 2017 to April 2021. According to whether the patients had myocardial injury, they were divided into 39 cases in the myocardial injury group and 49 cases in the non-myocardial injury group; the other healthy patients were selected during the same period. Fifty cases of the physical examination were the control group. All patients underwent echocardiography and HbA1c and MOP levels. Compare the three-dimensional echocardiographic parameters of each group [diastolic posterior wall thickness (LVPWd), systolic left ventricular posterior wall thickness (LVPWs), total left atrial ejection volume (LASV), left atrial dilatation index (LAEI), left Total Atrial Ejection Fraction (LAEF)] and serological indicators (BNP, cTnI, HbA1c, MOP) differences. The ROC curve analyzes the value of each index in predicting the risk of septic myocardial injury, and Logistic regression analyzes the influencing factors of septic myocardial injury.Results: Comparison of the three groups of LVPWd, LVPWs, LASV, LAEI, LAEF, HbA1c, MOP, BNP, cTnI, the difference was statistically significant (P<0.05). LASV, LAEI, LAEF, HbA1c, MOP, BNP, cTnI value control group> non-myocardial injury group> myocardial injury group (P<0.05); LVPWd, LVPWs level control group