摘要: |
目的 研究帕金森病患者(PD)的左室心肌质量指数(LVMI)并对相关影响因素进行探讨。方法 选取临床诊断的PD患者75例,根据H-Y分级分为早期与中晚期两个亚组,以及年龄、性别相匹配的健康对照组75例,收集患者的相关资料包括年龄、性别、病程、美多芭等效剂量等。应用实时三维超声心动图(RT-3DE)测量不同PD亚组患者和健康对照组的LVMI以及左心室收缩功能指标包括左室舒张末容积指数(LVEDVI)、左室每搏指数(LVSVI)及左室射血分数(LVEF)。结果 中晚期PD患者的LVMI较早期PD患者以及健康对照组减小(p<0.05),中晚期PD患者的LVSVI、LVEF较早期患者及健康对照组降低(均p<0.05),其他指标在PD不同亚组间、以及PD组与健康对照组间无明显差异。PD患者的LVMI与UPDRS评分、病程、美多芭等效剂量存在负相关(r=-0.512,-0.438,-0.621,均p<0.05),而与患者的年龄、性别等无关。结论 利用RT-3DE测得中晚期PD患者的LVMI减小,LVSVI、LVEF降低,可见在病程的中晚期,PD患者的心脏功能也受累,这可能有助于评估PD对心脏功能的影响程度。 |
关键词: 帕金森病 实时三维超声心动图 左室心肌质量指数 左心室功能 |
DOI: |
投稿时间:2022-04-05修订日期:2022-08-30 |
基金项目:国家自然科学基金项目(面上项目,重点项目,重大项目) |
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A clinical study of the change of myocardial mass in patients with Parkinson’s disease |
Wang Xiaoying,Chen Jing,Yang Xinxin |
(The affiliated Hospital of Xuzhou Medical University) |
Abstract: |
Objective To study the left ventricular mass index (LVMI) of patients with Parkinson’s disease and to explore the related factors. Methods Seventy-five clinically diagnosed PD patients were divided into two subgroups according to H-Y classification. In addition, 75 healthy controls matched for age and sex were involved. Relevant data were collected including age, sex, course of disease and madopar equivalent dose. Real-time three-dimensional ultrasound (RT-3DE) was used to measure LVMI and left ventricular function including left ventricular end-diastolic volume index (LVEDVI), left ventricular stroke volume index (LVSVI) and left ventricular ejection fraction (LVEF). These indexes were all measured in different PD subgroups and normal controls. Results LVMI of PD patients in middle and late stage was lower than that of early stage and control group (p<0.05). LVSVI, LVEF of PD patients in middle and late stage were lower than that of early stage and control group (all p<0.05). There were no significant differences in other indexes between PD subgroups or between PD group and healthy control group. Correlation analysis showed that there is an obvious negative correlation between LVMI and UPDRS score, disease duration and Madopar equivalent dose (r=-0.512, -0.438, -0.621, all p<0.05). Conclusions By using RT-3DE, LVSVI and LVEF and LVMI decreased in patients with intermediate and advanced PD. It can be seen that in the middle and late stages of the disease, the heart function of PD patients is also affected, which may be helpful to evaluate the degree of influence of PD on the heart. |
Key words: Parkinson’s disease Real-time three-dimensional ultrasound Left ventricular mass index Left ventricular function |