| 摘要: |
| 目的：探讨对甲状腺良性结节超声引导下经皮激光消融（percutaneous laser ablation，PLA）的疗效及影响因素。方法：对164例接受PLA治疗的甲状腺良性结节的临床资料进行回顾性分析，对其术后2年的随访资料进行评估，包括结节的体积及体积缩小率（volume reduction ratio，VRR），并评价影响PLA疗效的相关因素。结果：甲状腺良性结节PLA术后2年内体积明显缩小，对比术前差异有统计学意义（P均<0.05），术后1、3、6、12、18及24个月VRR分别为：（5.2±71.1）%，（45.5±41.7）%，（70.4±26.3）%，（86.3±16.3）%，（87.8±15.6）%，（89.2±15.1）%；甲状腺结节按内部成分不同分组，术后1、3个月组间VRR差异具有统计学意义（P＜0.05），以囊性为主的结节VRR更大；将实性结节按照体积分组，术后6个月至24个月组间VRR差异有统计学意义（P均＜0.001）， 5ml以下的实性结节消融后VRR更大。多元线性回归分析显示，结节初始体积是影响随访终点VRR唯一影响因素。结论：PLA治疗甲状腺良性结节是一种安全、有效的微创治疗方法，结节初始体积是对术后VRR唯一影响因素。 |
| 关键词: 超声引导 经皮激光消融 疗效 甲状腺良性结节 |
| DOI： |
| 投稿时间：2022-04-23修订日期：2022-05-31 |
| 基金项目:WNT10A调控Tec/STAT3通路促进PTMC增殖、侵袭和转移的机 制及风险预测模型研究 ， |
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| The effect and influencing factors of ultrasound-guided percutaneous laser ablation for the treatment of benign thyroid nodules |
| Dai ting,Zhou ping,Liu wengang |
| () |
| Abstract: |
| Objective: To explore the curative effect and influencing factors of ultrasound (US)-guided percutaneous laser ablation (PLA) for benign thyroid nodules. Methods: The study included 164 benign thyroid nodules and followed up 2 years after the PLA treatment. Nodule volume and VRR were evaluated before PLA treatment and during follow-up. The factors related to efficacy were evaluated. Results :The volume of benign thyroid nodules after the PLA treatment was significantly reduced after 1, 3, 6, 12，18，24 months, and their nodule VRR was（5.2±71.1）%，（45.5±41.7）%，（70.4±26.3）%，（86.3±16.3）%，（87.8±15.6）%，（89.2±15.1）% respectively. The thyroid nodules were divided into 3 groups according to the cystic portion, significant differences were found in the VRR at 1 and 3 months after PLA ( P＜0.05), the cystic nodule were the fastest one the lesion shrunk. The nodules with the solid portion were grouped according to the volume of the nodules ( ≤ 5 ml /5～10ml/＞10ml); and significant differences were found in the VRR at 6~24 months after PLA (The VRR of nodules of which the volume ≤ 5 ml was larger). Multiple linear regression analysis showed that initial nodule volume (P<0.001) was the only independent factors predicting final VRR. Conclusions: US-guided PLA is a safe and effective minimally invasive therapy for benign thyroid nodules. The initial volume of the nodules will affect the postoperative VRR. |
| Key words: Ultrasound guided, Benign thyroid nodule Percutaneous laser ablation Treatment effect |
