Objective To evaluate left ventricular systolic function in gout patients with two-dimensional speckle tracking imaging (2D-STI).Methods 60 gout patients were selected and divided into group I (duration of disease <10 years,30 cases) and group II (duration of disease ≥10 years,30 cases) according to the course of disease, and 30 cases of healthy control group were selected. Conventional parameters were measured by transthoracic echocardiography, and 2D-STI was used to obtain the left ventricular global longitudinal strain (LVGLS) and the longitudinal strain values of each section (LVLS-AP4,AP2,AP3),and the differences in the above data between groups were compared. The serum uric acid and creatinine levels of three groups of subjects were detected and the differences were compared. Pearson and Spearson correlation was used to analyze whether there was a correlation between LV GLS and serum uric acid, creatinine and disease duration. Results Serum uric acid and creatinine levels in gout groups I and II were significantly higher than those in the control group, and the difference was statistically significant (P<0.05). There were significant differences in IVS,LVEDD,LVPW,LVESD,LVEDV, LVESV between gout groups I and II compared with the normal control group, but there was no obvious difference between the gout groups.Compared with the control group,the global and each section longitudinal peak strains of the left ventricle in gout groups I and II were decreased (P<0.05).The result of correlation analysis showed there was no correlation between LV GLS and serum uric acid and creatinine levels (all P>0.05).However LV GLS was negatively correlated with disease duration (r=-0.477，P<0.05).Conclusion The left ventricular systolic function of gout patients has been damaged,and the impairment of left ventricular systolic function increases with the extension of disease duration. 2D-STI technology can evaluate the changes of left ventricular systolic function in gout patients at early stages.