| 摘要: |
| 目的 应用超声二维斑点追踪成像(two-dimensional speckle tracking imaging,2D-STI)技术评价痛风患者左心室收缩功能。方法 选取60例痛风患者,根据病程分为Ⅰ组(病程＜10年,30例)和Ⅱ组(病程≥10年,30例),另选健康对照组30例。经胸超声心动图测量常规参数,应用2D-STI获取左室整体纵向应变值(Left ventricular global longitudinal strain,LVGLS)和四腔、两腔、三腔切面纵向应变值(LVLS-AP4、AP2、AP3),比较各组间上述数据的差异。使用Pearson和Spearson相关性分析LVGLS与血清尿酸、肌酐及病程之间是否存在相关性。结果 痛风组血清尿酸及肌酐水平明显高于对照组,差异有统计学意义(P＜0.05)。痛风I组和II组IVS、LVEDD、LVPW、LVESD、LVEDV、LVESV与对照组比较差异均有统计学意义,但I组和II组间比较未见明显差异性；痛风I组和II组左室整体及各切面纵向峰值应变均小于对照组(P＜0.05)。相关性分析结果表明,痛风患者的LV GLS与血清尿酸、肌酐水平均无明显相关性(均P＞0.05)),与病程时间呈中度负相关(r=-0.477,P＜0.05)。结论 痛风患者左心室收缩功能已经受损,随着疾病时间的延长,左室收缩功能受损程度加重, 2D-STI技术可以用于评估痛风患者早期左心室收缩功能变化。 |
| 关键词: 二维斑点追踪成像技术 痛风 心室收缩功能，左 超声心动图 |
| DOI： |
| 投稿时间：2022-04-26修订日期：2022-06-21 |
| 基金项目:安徽省2017年公益性技术应用研究联动计划项目（1704f0804048）；2020年年度芜湖市科技计划项目（2020ms3-5） |
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| Evaluation of left ventricular systolic function in gout patients by two-dimensional speckle tracking |
| SHI Zixuan,ZHANG Xia,ZHAO Tianying,SHEN Qing,JI Xinyue |
| (Department of Ultrasound,Yijishan Hospital,The First Affiliated Hospital of Wannan Medical College) |
| Abstract: |
| Objective To evaluate left ventricular systolic function in gout patients with two-dimensional speckle tracking imaging (2D-STI).Methods 60 gout patients were selected and divided into group I (duration of disease <10 years,30 cases) and group II (duration of disease ≥10 years,30 cases) according to the course of disease, and 30 cases of healthy control group were selected. Conventional parameters were measured by transthoracic echocardiography, and 2D-STI was used to obtain the left ventricular global longitudinal strain (LVGLS) and the longitudinal strain values of each section (LVLS-AP4,AP2,AP3),and the differences in the above data between groups were compared. The serum uric acid and creatinine levels of three groups of subjects were detected and the differences were compared. Pearson and Spearson correlation was used to analyze whether there was a correlation between LV GLS and serum uric acid, creatinine and disease duration. Results Serum uric acid and creatinine levels in gout groups I and II were significantly higher than those in the control group, and the difference was statistically significant (P<0.05). There were significant differences in IVS,LVEDD,LVPW,LVESD,LVEDV, LVESV between gout groups I and II compared with the normal control group, but there was no obvious difference between the gout groups.Compared with the control group,the global and each section longitudinal peak strains of the left ventricle in gout groups I and II were decreased (P<0.05).The result of correlation analysis showed there was no correlation between LV GLS and serum uric acid and creatinine levels (all P>0.05).However LV GLS was negatively correlated with disease duration (r=-0.477，P<0.05).Conclusion The left ventricular systolic function of gout patients has been damaged,and the impairment of left ventricular systolic function increases with the extension of disease duration. 2D-STI technology can evaluate the changes of left ventricular systolic function in gout patients at early stages. |
| Key words: Two-dimensional speckle tracking imaging Gout Ventricular systolic function, left Echocardiography |
