| 摘要: |
| 目的 分析甲状腺乳头状癌（PTC）二维超声图像特征及BRAF V600E突变与颈部淋巴结转移的关系。方法 选取于我院行甲状腺癌根治术患者316例，根据甲状腺癌术后病理分期（pTNM），将无颈部淋巴结转移（pN0）者归为（未转移组），有颈部淋巴结转移（pN1）者归为转移组，比较两组二维超声图像特征、临床资料、BRAF V600E突变的差异。采用多因素Logistic回归分析PTC超声图像特征、BRAF V600E突变与颈部淋巴结转移的关系。结果 316例PTC患者中，转移组156例（49.4%），98例（62.8%）发生BRAF V600E突变；未转移组160例（50.6%），121例（75.6%）发生BRAF V600E突变。转移组与未转移组在年龄、病灶数目、大小、沙粒钙化、纵横比、肿瘤边缘、病灶与被膜关系、累及腺叶比较，差异均有统计学意义（均P＜0.05）。多因素Logistic回归分析显示，患者年龄、肿瘤大小、沙粒钙化、纵横比、病灶与被膜关系、累及腺叶是发生颈部淋巴结转移的危险因素（均P＜0.05）。结论 PTC颈部淋巴结转移与患者年龄、肿瘤大小、沙粒钙化、纵横比、病灶与被膜、累及腺叶关系有关，与性别、病灶数目、肿瘤边缘、BRAF V600E突变无关。 |
| 关键词: 超声检查 甲状腺乳头状癌 声像图特征 颈部淋巴结转移 基因突变 |
| DOI： |
| 投稿时间：2022-05-12修订日期：2023-03-16 |
| 基金项目:甲状腺结节风险分层及甲状腺癌早期诊断关键技术(cstc2017shmsA130006) |
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| Correlation analysis of ultrasound characteristics, BRAFV600E gene mutation and cervical lymph node metastasis in papillary thyroid carcinoma |
| zhoufang,zhanggang,lihuan,zhangzhe,luodonglin |
| () |
| Abstract: |
| ABSTRACT Objective To analyze the characteristics of two-dimensional ultrasound images of papillary thyroid carcinoma (PTC) and the relationship between BRAFV600E mutation and cervical lymph node metastasis. Methods 316 patients with thyroid cancer underwent radical surgery in our hospital were selected. According to the pathological stage (pTNM) of thyroid cancer after surgery, those without cervical lymph node metastasis (pN0) were classified as (non metastasis group), and those with cervical lymph node metastasis (pN1) were classified as (metastasis group). The differences of two-dimensional ultrasound image characteristics, clinical data and BRAFV600E mutation between the two groups were compared. Multi-factor logistic regression analysis was used to analyze the characteristics of PTC ultrasound image and the relationship between BRAFV600E mutation and cervical lymph node metastasis. ResuLts Among 316 PTC patients, 156 (49.4%) in the metastatic group, 98 (62.8%) had BRAFV600E mutation; 160 (50.6%) in the non-metastatic group, 121 (75.6%) had BRAFV600E mutation. There were statistically significant differences between the metastatic group and the non-metastatic group in terms of age, number and size of lesions, sand calcification, aspect ratio, tumor margin, the relationship between lesions and membrane,and involvement of glandular lobes (all P<0.05). Multivariate logistic regression analysis showed that patients' age, tumor size, sand calcification, aspect ratio, the relationship between lesion and membrane, and the involvement of glandular lobe were risk factors for pN1（all P< 0.05）.
Conclusion The cervical lymph node metastasis of PTC is related to the patient's age, tumor size, sand calcification, aspect ratio, the relationship between the lesion and membrane, and the glandular lobe involved, but not to gender, number of lesions, tumor margin, and BRAF V600E mutation. |
| Key words: Papillary thyroid carcinoma Two-dimensional pangraph features Cervical lymph node metastasis Genetic mutations |
