| 摘要: |
| 目的 探讨剪切波弹性成像（SWE）在新生儿缺氧缺血性脑病（HIE）的早期诊断和疗效评估中的应用价值。方法 选取于我院行颅脑超声检查的78例新生儿，并依据HIE诊断标准分为正常组和HIE组，再以出生时孕周37周为界分为早产组和足月组，并巢式分布于正常组和HIE组。应用SWE测量所有新生儿丘脑、额叶弹性模量值，分析比较新生儿脑组织不同区域弹性模量值差异，以及正常组与HIE组丘脑、额叶弹性模量值的差异。HIE组治疗7 d后复查，比较治疗前后丘脑、额叶弹性模量值的差异，对于治疗后病情加重的患儿于治疗约3周后再次进行复查对比。结果 两组中丘脑的弹性模量值均高于额叶，差异均有统计学意义（均P＜0.001）；HIE组丘脑、额叶弹性模量值均高于正常组，差异均有统计学意义（均P＜0.05）；HIE组治疗后丘脑、额叶弹性模量值均低于治疗前，差异均有统计学意义（均P＜0.001）；HIE组中3例患儿治疗7天后丘脑、额叶弹性模量值较前增加，在治疗20天后弹性模量值出现下降。结论 SWE可以为HIE的诊断和疗效评估提供一个量化指标，为临床医师诊疗活动提供更有价值的参考信息。 |
| 关键词: 超声检查；缺氧缺血 剪切波 弹性成像 丘脑 额叶 |
| DOI： |
| 投稿时间：2022-05-18修订日期：2022-11-26 |
| 基金项目:湖北省卫生计生委科研项目《常规超声联合SWE预测早产的临床价值研究》 (WJ2019H541) |
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| Study on the application value of shear wave elastography in the diagnosis and curative effect evaluation of hypoxic-ischemic encephalopathy |
| Che pengfei,Hu bing,Hu bing,Wu qiying |
| () |
| Abstract: |
| Objective To explore the application value of shear wave elastography（SWE） in the early diagnosis and curative effect evaluation of neonatal hypoxic-ischemic encephalopathy.Methods 78 newborns were selected as subjects and divided into normal group and HIE group according to the diagnostic criteria of HIE.According to the 37 weeks of gestation at birth，they were divided into premature infants，full-term infants，and were nested distribution in normal group and HIE group.The elastic modulus of thalamus and frontal lobe of each newborn was measured by SWE，and the differences of elastic modulus values in different regions of neonatal brain tissue, as well as those of thalamus and frontal lobe between normal group and HIE group were analyzed and compared.The HIE group was reexamined 7 days after treatment，and the differences of elastic modulus of thalamus and frontal lobe before and after treatment were compared.?For the children who got worse after treatment, reexamination was made after about 3 weeks of treatment.Results The elastic modulus of thalamus was higher than that of frontal lobe in both groups, and the difference was statistically significant (both P ＜ 0.001). The elastic modulus of thalamus and frontal lobe in HIE group was higher than that in normal group（P＜0.05）.After treatment，the elastic modulus of thalamus and frontal lobe in HIE group was lower than that before treatment（P＜0.001）.The elastic modulus of thalamus and frontal lobe of 3 children in HIE group increased after 7 days of treatment, and decreased after 20 days of treatment.Conclusion SWE can provide a quantitative index for the diagnosis and efficacy evaluation of HIE，and provide more valuable reference information for clinicians' diagnosis and treatment activities. |
| Key words: ultrasonic examination,hypoxia-ischemia, shearwave, elastography, thalamus, frontal lobe |
