ABSTRACT Objective To explore the role of pulmonary artery pressure score combined with pulmonary ultrasound score in early evaluation of bronchopulmonary dysplasia（BPD） in premature infants.Methods A total of 169 neonatal infants admitted to the neonatal ward of our hospital from May 2016 to August 2020 were collected.，including 92 BPD and 77 non-BPD. The evaluation of the pulmonary artery pressure at 4-7，8-14，15-21，and 22-28 days and the score of the maximum pulmonary artery pressure within 4-28 days after birth were done by a senior cardiac ultrasound doctor. The lung sonography scores were completed within 24-28 days after birth by a senior ultrasonologist. The ultrasound changes in early BPD formation was analyzed by univariate and multivariate analysis. Through diagnostic test evaluation，the early evaluation value of pulmonary artery pressure score combined with pulmonary ultrasound score in bronchopulmonary dysplasia was verified. Results Both univariate and multivariate analysis showed that echocardiographic indexes（maximum pulmonary hypertension within 4-28 days after birth） and lung ultrasound indexes（rough thickening of pleura，cystic degeneration and rough diaphragm） were risk factors for BPD. And the differences were statistically significant（P＜0.05）. There were significant differences in gestational age（weeks）,birth weight（g）,pulmonary artery pressure score,pulmonary ultrasound score and combination score between BPD group and non-BPD group.Pulmonary artery pressure score can be used to early diagnose BPD（P＜0.05），AUC（95%CI） = 0.749（0.675-0.823），and pulmonary artery pressure score combined with pulmonary ultrasound score can be used to early diagnose BPD（P＜0.05），AUC（95%CI） = 0.952（0.925-0.980）. The optimal cutoff points were 1.5 for pulmonary artery pressure score and 4 for combination score.Conclusion Pulmonary artery pressure score of the maximum pulmonary artery pressure within 4-28 days after birth can be used to early diagnose BPD. The efficacy of pulmonary artery pressure score combined with pulmonary ultrasound score in early evaluation of BPD is significantly better than that of pulmonary artery pressure score alone.