| 摘要: |
| 目的 探讨并比较不同分子亚型的乳腺癌患者超声影像学特征。方法 回顾性分析2019年3月~2021年3月在本院收治的130例乳腺癌患者,根据免疫组织化学检测结果将患者分为管腔A型(Luminal A型)(n=38)、管腔B型(Luminal B型)(n=41)、三阴型(n=29)及原癌基因人类表皮生长因子受体2(HER-2) 过表达型 (n=22)。记录并比较四组患者临床资料、影像学特征、病理学特点,分析病理学特点与影像学特征的关系。结果 四组患者在组织学分级、淋巴结转移情况、肿瘤直径、肿瘤边界、回声类型、后方回声、肿瘤形态、肿瘤钙化、血流分级比较上具有显著差异(P＜0.05)；其中Luminal 型超声影像学特征以毛刺状、低回声、无钙化、形态不规则、0~Ⅰ级血流为主；三阴型超声影像学特征以微分叶、低回声、后方回声增强、形态不规则、无钙化及Ⅱ~Ⅲ级血流为主；HER-2过表达型超声影像学特征以模糊、低回声、后方回声增强、形态不规则、有钙化及Ⅱ~Ⅲ级血流为主。Ⅰ级、Ⅱ级、Ⅲ级乳腺癌患者在血流及肿瘤形态比较上差异具有统计学意义(P＜0.05)。结论 不同分子亚型的乳腺癌患者具有一定的超声影像学特征及病理特点,临床可根据影像学特征、病理特点确定分子亚型,并以此选择个体化治疗方案,以期改善预后,延长患者生存期。 |
| 关键词: 分子亚型 乳腺癌 超声 影像学特征 病理学特点 |
| DOI： |
| 投稿时间：2022-07-05修订日期：2022-07-29 |
| 基金项目: |
|
| Comparison of ultrasonic imaging characteristics in breast cancer patients with different molecular subtypes |
| Li Ying |
| () |
| Abstract: |
| Objective To explore and compare ultrasonic imaging characteristics in breast cancer patients with different molecular subtypes. Methods A retrospective analysis was performed on the 130 patients with breast cancer admitted to the hospital between March 2019 and March 2021. According to the results of immunohistochemistry, they were divided into luminal A group (Luminal A, n=38), luminal B group (Luminal B, n=41), triple-negative group (n=29) and proto-oncogene human epidermal growth factor receptor 2 (HER-2) overexpression group (n=22). The clinical data, imaging characteristics and pathological characteristics in the four groups were recorded and compared. The relationship between pathological characteristics and imaging characteristics was analyzed. Results There were significant differences in histological grading, lymph node metastasis, tumor diameter, tumor boundary, echo types, posterior echo, tumor morphology, tumor calcification and blood flow grading among the four groups (P<0.05). The main ultrasonic imaging characteristics in Luminal type included spicule sign, low echo, no calcification, irregular morphology and grade 0-I blood flow. The main ultrasonic imaging characteristics in triple-negative type included micro-lobulation sign, low echo, posterior echo enhancement, irregular morphology, no calcification and grade II-III blood flow. The main ultrasonic imaging characteristics in HER-2 overexpression type included blurred sign, low echo, posterior echo enhancement, irregular morphology, calcification and grade II-III blood flow. There were significant differences in blood flow and tumor morphology among patients with breast cancer at grades I, II and III (P<0.05). Conclusion There are certain ultrasonic imaging characteristics and pathological characteristics in breast cancer patients with different molecular subtypes. Clinically, molecular subtypes can be determined according to imaging characteristics and pathological characteristics. Individualized treatment regimens can be selected based on these to improve prognosis and prolong patients survival. |
| Key words: Molecular subtype Breast cancer Ultrasound Imaging characteristic Pathological characteristic |
