【Abstract】 Objective: To analyze the consistency of contrast-enhanced ultrasound (CEUS) and color Doppler flow quantification (CDFQ) in renal blood perfusion in chronic kidney disease (CKD).Methods: 62 CKD patients admitted to our hospital from January 2020 to January 2022 were selected, and relevant laboratory indicators were collected at the time of admission. According to the CKD guidelines formulated by the NKF-K/DOQI working group of the United States, patients were divided into three groups according to the glomerular filtration rate (eGFR) value: mild group (15 cases, eGFR≥60mL/min/1.73m2), moderate group (25 cases, 59≤eGFR ≤45mL/min/1.73m2), and severe group (22 cases, eGFR<45mL/min/1.73m2). All patients were examined by color Doppler flow imaging (CDFI) to obtain relevant ultrasonic quantitative indicators [vascular index (VI), blood flow index (FI), vascular blood flow index (VFI)]. Time intensity curve (TIC) parameters such as peak intensity (DPI), time to peak (TTP) and area under the curve (AUC) were obtained by contrast-enhanced ultrasound. The consistency of renal blood flow perfusion evaluated by CEUS and ultrasonic quantitative indexes was analyzed. Results: VF and II in mild group were higher than those in moderate group and severe group, and VF and II in moderate group were higher than those in severe group, with significant difference (P<0.05); DPI and AUC in mild group were higher than those in moderate group and severe group, and DPI and AUC in moderate group were higher than those in severe group; TTP in mild group was less than that in moderate group and severe group, and TTP in moderate group was less than that in severe group, with significant difference (P<0.05); FI, VI, VFI, DPI and AUC were all positively correlated with each other and negatively correlated with TTP (P<0.05); The consistency between CEUS and ultrasound quantitative indexes in evaluating the decrease of renal blood flow perfusion in mild and moderate groups was acceptable (P<0.05), and the consistency in evaluating the decrease of renal blood flow perfusion in severe group was better (kappa value =0.831, P<0.05). Conclusion: The consistency of ultrasound quantitative indexes and CEUS parameters in evaluating renal blood flow perfusion in CKD patients is acceptable, and the consistency is the best when evaluating patients with eGFR<45mL/min/1.73m2.