Objective To prepare chlorine e6 （Ce6）-loaded ultrasound nanobubbles （NB）targeting atherosclerotic plaque scavenger receptor-A （SR-A），and to explore the effect to enhance the targetable ability and sonodynamic efficacy of sonosensitizers. Methods Nanobubbles （Ce6-PP1 NB） with Ce6 and SR-A-targeted peptides PP1 were prepared by the film hydration method，then their physicochemical properties and cytocompatibility were assessed. Mouse leukemia cells of monocyte macrophage （RAW264.7 cells） were co-incubated with Ce6 and Ce6-PP1 NB，respectively，then the intracellular fluorescence of Ce6 was observed by confocal laser scanning microscope （CLSM） to evaluate the targetable ability of Ce6-PP1 NB.RAW264.7 cells were divided into four groups：control， low-intensity pulsed ultrasound （LIPUS），Ce6+LIPUS and Ce6-PP1 NB+LIPUS.Next，the sonosensitivity and sonodynamic efficacy of Ce6-PP1 NB were evaluated by DCFH-DA staining，flow cytometry，and ELISA assays. Results Ce6-PP1 NB presented a regular spherical shape and homogenized dispersion with the average particle size of （504.25±149.13）nm，the zeta potential of （-8.67±0.78）mV，Ce6 encapsulation efficiency of （85.63±4.39）% and PP1 loaded capacity of （92.78%±4.57）%.CLSM showed more significant intracellular red fluorescence of Ce6 in the Ce6-PP1 NB group than in the Ce6 group.Compared to cells in Ce6+LIPUS，cells in Ce6-PP1 NB +LIPUS manifested distinct intracellular green fluorescence and secreted less tumor necrosis factor-α （TNF-α） and interleukin-6 （IL-6） but more interleukin-10 （IL-10），with the decreasing M1 phenotype while the increasing M2 phenotype，suggesting that the sonodynamic efficacy of Ce6-PP1 NB+LIPUS was superior to that of Ce6+LIPUS. Conclusion The successfully constructed Ce6-PP1 NB is expected to improve the targeting ability and sonodynamic efficacy of sonosensitizers in atherosclerotic plaque.