| 摘要: |
| 目的：分析超声 FibroTouch 受控衰减参数对不同程度脂肪肝的评估价值。方法：于2018年6月-2022年1月期间在本院选择120例不同程度脂肪肝的患者,定义为检测组,并随机选择明确无脂肪肝的健康志愿者50例作为对照组,两组患者均采用FibroTouch 检测和肝活检检查。构建受试者工作特征(ROC)曲线,通过曲线下面积(AUC)的差异以及脂肪衰减参数等,判断脂肪肝病变程度,并计算敏感度和特异度。采用多元线性回归分析,建立回归方程,了解影响受控衰减参数的因素。结果：对照组和轻度、中度、重度脂肪肝患者的受控衰减参数分别为(198.52±18.54) dB/m、(245.56±17.62) dB/m、(286.97±23.49)dB/m 和(342.82±20.55) dB/m；轻度、中度、重度脂肪肝患者的AUC分别为0.952、0.976、0.982,对应的诊断截断点分别为245 dB/m、266 dB/m、299 dB/m,诊断不同程度脂肪肝患者的敏感度和特异度均在85%以上。影响受控衰减参数的因素主要有BMI、脂肪变程度、甘油三酯、气球样变、肝脏硬度等,与胰岛素水平、谷丙转氨酶等无关。结论：不同程度脂肪肝可以通过超声 FibroTouch 受控衰减参数进行评估,敏感性和特异性均较好。 |
| 关键词: FibroTouch受控衰减参数 脂肪肝 超声 无创诊断 |
| DOI： |
| 投稿时间：2022-08-16修订日期：2022-09-27 |
| 基金项目: |
|
| Evaluation of ultrasound fibrotouch controlled attenuation parameters in different degrees of fatty liver |
| He Guohua,Liu Lin,Zhao Qiang,Li Ting,Li Hongguang |
| () |
| Abstract: |
| Objective: To analyze the value of ultrasound fibrotouch controlled attenuation parameters in the evaluation of different degrees of fatty liver. Methods: From June 2018 to June 2022, 120 patients with different degrees of fatty liver were selected as the test group, and 50 healthy volunteers without fatty liver were randomly selected as the control group. Both groups were tested by fibrotouch and liver biopsy. Construct the receiver operating characteristic (ROC) curve, judge the degree of fatty liver disease through the difference of area under the curve (AUC) and fat attenuation parameters, and calculate the sensitivity and specificity. Multiple linear regression analysis is used to establish the regression equation to understand the factors affecting the controlled attenuation parameters. Results: The controlled attenuation parameters of the control group and patients with mild, moderate and severe fatty liver were (198.52 ± 18.54) dB / m, (234.56 ± 17.62) dB / m, (286.97 ± 23.49) dB / M and (342.82 ± 20.55) dB / m, respectively; The AUC of patients with mild, moderate and severe fatty liver were 0.952, 0.976 and 0.982 respectively, and the corresponding diagnostic cutoff points were 225 dB / m, 256 dB / M and 291 dB / m respectively. The sensitivity and specificity of diagnosing patients with different degrees of fatty liver were more than 85%. The main factors affecting the controlled attenuation parameters were BMI, degree of steatosis, triglyceride, balloon like change, liver hardness, etc., which had nothing to do with insulin level, alanine aminotransferase, etc. Conclusion: Different degrees of fatty liver can be evaluated by ultrasound fibrotouch controlled attenuation parameters, with good sensitivity and specificity. |
| Key words: fibrotouch controlled attenuation parameter Fatty liver Ultrasound Noninvasive diagnosis |
