| 摘要: |
| 目的 探讨2型糖尿病（T2DM）患者动脉弹性指标与心血管耦联关系的初步研究。方法 选取T2DM患者89例及年龄、性别匹配者54例（对照组），依据是否合并高血压分为糖尿病血压正常组（DM组）和糖尿病合并高血压组（DM+HBP组）。分别获取受试者收缩压、舒张压、中心动脉收缩压、中心动脉脉压、动脉波速指数（AVI）、动脉压力容积指数（API）、有效动脉弹性（Ea）、左心室收缩末期弹性（Ees）和心血管耦联指数（VVI，VVI=Ea/Ees）。组间比较采用方差分析，相关分析采用Spearman相关分析。结果 ①DM+HBP组受试者收缩压、舒张压、中心动脉收缩压和中心动脉脉压均高于对照组和DM组受试者（P均<0.05）。②DM+HBP组受试者AVI、API和Ea大于DM组和对照组受试者（P均<0.05）。而Ees和VVI在三组间差异无统计学意义（P＞0.05）。③Ea分别与年龄、收缩压、中心动脉收缩压、中心动脉脉压和AVI成正相关（P均<0.05）。Ees分别与收缩压、中心动脉收缩压和AVI成正相关（P均<0.05）。结论 糖尿病患者动脉弹性和心室弹性同步增大，二者匹配耦联；增大的新动脉弹性指标与心血管耦联指标正相关。 |
| 关键词: 糖尿病 心室弹性 动脉弹性 心血管耦联 高血压 |
| DOI： |
| 投稿时间：2022-08-19修订日期：2023-03-03 |
| 基金项目:上海市自然科学基金;上海市嘉定区卫生和计划生育委员会基金;上海市嘉定区江桥医院“科技计划”项目 |
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| A preliminary study of the relationship between novel arterial stiffness indices and ventricular-vascular coupling |
| wulingheng,chenjianxiong,zhangmengjiao,shalei,caomengmeng,shencuiqin,dulianfang,lizhaojun |
| (Mindong Hospital Affiliated to Fujian Medical University;Shanghai General Hospital, Shanghai Jiaotong University) |
| Abstract: |
| Objective The preliminary study to explore the relationship between novel arterial stiffness indices and ventricular–vascular coupling in patients with type 2 diabetes mellitus (T2DM).Methods Eighty-nine patients with T2DM were divided into two groups according to combined with hypertension (HBP) or not: diabetes mellitus with normal blood pressure (DM) group and diabetes mellitus with HBP (DM+HBP) group. Fifty-four age-and gender-matched subjects were in the control group. Systolic blood pressure, diastolic blood pressure, central systolic blood pressure, central artery pulse pressure, the arterial velocity pulse index (AVI), the arterial pressure volume index (API), effective arterial elasticity (Ea), left ventricular end-systolic elastance (Ees) and ventricular-vascular coupling index (VVI, VVI=Ea/Ees) were obtained from the subjects respectively. The parameters were compared by variance analysis. The correlation analysis was performed by Spearman correlation analysis. Results ①The systolic blood pressure, the diastolic blood pressure, the central systolic blood pressure and the central artery pulse pressure were higher in the DM+HBP group than in the DM group and the control group (all P＜0.05). ②AVI, API and Ea were higher in the DM+HBP group than in the DM group and the control group (all P＜0.05), but Ees and VVI was no significant difference among the three groups (all P＞0.05). ③Ea was positively correlated with age, systolic blood pressure, central systolic blood pressure, central artery pulse pressure and AVI (all P<0.05). Ees was positively correlated with systolic blood pressure, central systolic blood pressure and AVI (all P<0.05).Conclusions Arterial elasticity and ventricular elasticity increase in parallel in diabetic patients, and the two are matched coupled; increased novel arterial stiffness indices positively correlates with the indices of ventricular–vascular coupling. |
| Key words: Type 2 diabetes mellitus Ventricular elasticity Arterial elasticity Ventricular–vascular coupling Hypertension |
