| 摘要: |
| 目的 分析基于超声衰减成像对非酒精性脂肪肝(NAFL)的诊断价值及其与NAFL严重度的关系。方法 选取2018年1月～2021年6月在我院经确诊为NAFL的患者85例设为观察组,其中轻、中、重度NAFL分别25例、35例、25例,选取同期正常肝脏受检者25例作为对照组,两组均行常规肝脏超声与超声衰减成像检查,比较对照组与不同病情程度NAFL患者,一般资料与脂代谢指标[总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)],肝弹受控衰减参数(controlled attenuation parameters,CAP),并采用组内相关系数(ICC)评价测值稳定性,pearson相关性分析CAP与脂代谢指标、体质量指数(BMI)的相关性,受试者特征曲线(ROC)分析超声衰减成像参数诊断不同病情程度NAFL的应用价值。结果 对照组与轻、中、重度NAFL患者BMI、TC、TG均呈上升趋势,HDL-C呈下降趋势,轻、中、重度NAFL患者BMI、TC、TG均高于对照组,HDL-C都低于对照组(P＜0.05)；对照组与轻、中、重度NAFL患者CAP值呈上升趋势,轻、中、重度NAFL患者CAP值均高于对照组(P＜0.05)；对照组与轻、中、重度NAFL患者操作者内 ICC均高于0.750；pearson相关性分析结果显示,CAP与BMI、TC、TG呈正相关性,与HDL-C呈负相关性(P＜0.05)；ROC分析显示,超声衰减成像参数诊断轻、中、重度NAFL的AUC分别为0.838、0.864、0.961(P＜0.05)。结论 超声衰减成像具较高诊断效能,其能够定量评估NAFL病情严重程度,可应用于临床鉴别NAFL及指导治疗。 |
| 关键词: 超声衰减成像 定量分析 非酒精性脂肪肝 病情严重程度 诊断 相关性 |
| DOI： |
| 投稿时间：2022-09-23修订日期：2022-10-21 |
| 基金项目: |
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| To analyze the diagnostic value of ultrasonic attenuation imaging in NAFL and its relationship with the severity of NAFL |
| zhangji,Li Jinyan,Yan yan |
| () |
| Abstract: |
| Objective To analyze the diagnostic value of quantitative ultrasound attenuation imaging for nonalcoholic fatty liver disease (NAFL) and its relationship with the severity of NAFL. Methods A total of 85 patients with NAFL confirmed in the hospital were enrolled as observation group between January 2018 and June 2021, including 25 cases, 35cases and 25 cases with mild, moderate and severe NAFL. A total of 25 controls with normal liver during the same period were enrolled as control group. Both groups underwent examinations of routine liver ultrasound and quantitative ultrasound attenuation imaging. The general data, lipid metabolism indexes [total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C)] and controlled attenuation parameters(CAP) were compared between control group and observation group. The stability of measurement values was evaluated by intra-class correlation coefficient (ICC). The correlation between CAP and lipid metabolism indexes, body mass index (BMI) was analyzed by pearson correlation analysis. The diagnostic value of quantitative ultrasound attenuation imaging parameters for different severity of NAFL was analyzed by receiver operating characteristic (ROC) curves. Results In control group and patients with mild, moderate and severe NAFL, BMI, TC and TG were increased, while HDL-C was decreased in turn. BMI, TC and TG in patients with mild, moderate and severe NAFL were higher than those in control group, while HDL-C was lower than that in control group (P<0.05). In control group and patients with mild, moderate and severe NAFL, CAP value was increased in turn. CAP value in patients with mild, moderate and severe NAFL was greater than that in control group (P<0.05). In control group and patients with mild, moderate and severe NAFL, ICC values were all greater than 0.750. The results of pearson correlation analysis showed that CAP was positively correlated with BMI, TC and TG, while negatively correlated with HDL-C (P<0.05). ROC curves analysis showed that AUC values of quantitative ultrasound attenuation imaging parameters in the diagnosis of mild, moderate and severe NAFL were 0.838、0.864and 0.961, respectively (P<0.05). Conclusion quantitative ultrasound attenuation imaging has high diagnostic efficiency, which can quantitatively evaluate the severity of NAFL, and can be applied in clinical differential diagnosis of NAFL and its guidance treatment. |
| Key words: Ultrasound attenuation imaging Quantitative analysis Nonalcoholic fatty liver disease Disease severity Diagnosis Correlation |
