| 摘要: |
| 目的 分析1~36月龄生长发育正常儿童在不同发育阶段超声骨密度的变化，建立闽西地区1~36月龄儿童超声骨密度参考数据库。方法 将1~36月龄生长发育正常儿童7485例分为1~3月龄、4~6月龄、7~9月龄、10~12月龄、13~24月龄、25~36月龄等6组，使用超声骨密度仪进行测量，比较不同月龄和性别儿童骨密度参数（超声信号声速值（SOS）、Z值）变化及骨密度不足检出率，采用多重线性回归分析骨密度相关影响因素。结果 在骨密度参数测值中，儿童SOS在1~3月龄逐渐下降，3月龄后逐渐升高。女童SOS在1~3月龄高于男童，在25~36月龄低于男童，差异均有统计学意义（均P＜0.05），其他年龄段男女童SOS比较差异均无统计学意义；在1~24月龄，男童Z值均大于女童，骨密度不足检出率均低于女童（P＜0.05）；在25~36月龄，男女童Z值和骨密度不足检出率比较差异均无统计学意义；与现有数据库比较，1~3月龄有高达51.29%的儿童骨密度不足，4~9月龄骨密度不足检出率均高于10%。多重线性回归表明，SOS与年龄、身长呈正相关，与体质量、性别呈负相关；Z值与身长、性别呈正相关，与体质量呈负相关（均P＜0.05）。结论 儿童骨密度随年龄和身长的增长而增加，1~9月龄是密度不足高发月龄，加强此月龄儿童骨密度早期筛查，有助于区分本地区骨密度不足高风险儿童，早期识别和治疗骨密度异常儿童，提高闽西地区儿童骨健康水平。 |
| 关键词: 超声检查 骨密度 定量超声 1-36月龄 闽西地区 |
| DOI： |
| 投稿时间：2022-11-14修订日期：2023-03-11 |
| 基金项目: |
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| Differences of bone mineral density in toddler in western Fujian province and its influencing factors |
| LI Zhenhui,FAN Kejin,LUO Yan |
| (Longyan First Hospital Affiliated to Fujian Medical University) |
| Abstract: |
| Objective To analyze the changes of bone mineral density（BMD） in toddlers aged 1~36 months with normal growth and development at different developmental stages，and to establish the reference database of ultrasound BMD in toddlers aged 1~36 months in western Fujian province.Methods 7485 toddlers aged 1~36 months with normal growth and development were divided into 6 groups，including 1~3 months，4~6 months，7~9 months，10~12 months，13~24 months，and 25~36 months.The BMD parameters were measured by ultrasound bone sonometers，the changes of BMD parameters（speed of sound（SOS），Z value）and the detection rate of BMD deficiency in toddlers of different month and sex were compared.Multiple linear regression was used to analyze the related influencing factors of BMD.Results In terms of BMD parameters，SOS of toddlers decreased gradually at 1~3 months and increased gradually after 3 months. girls’ SOS was higher than boys’ at 1~3 months and lower than boys’ at 25~36 months，with statistical significance（all P＜0.05），and there was no statistical significance in SOS between boys and girls at the remaining age groups； At 1~24 months，boys’ Z value was greater than girls’，and the detection rate of BMD deficiency of boys was lower than girls’（P＜0.05），At 25~36 months，there was no significant difference in Z value and the detection rate of BMD deficiency in boys and girls； Compared with the existing BMD databases，up to 51.29% of toddlers had BMD deficiency at 1~3 months，and the detection rate of BMD deficiency was higher than 10% at 4~9 months.Multiple linear regression showed that SOS was positively correlated with age and body length，and negatively correlated with body mass and sex； Z value was positively correlated with body length and sex，and negatively correlated with body mass（all P＜0.05）.Conclusion BMD of toddlers increases with age and body length.1~9 months is the high incidence month of BMD deficiency. Strengthening the early screening of BMD in toddler at these months can help distinguish toddler at high risk of BMD deficiency in local area，early detection and early treatment of toddlers with BMD abnormalities，and improve the bone health of toddlers in western Fujian province. |
| Key words: Ultrasonic examination Bone mineral density Quantitative ultrasound 1-36 months western Fujian province |
