Objective To investigate the application value of ultrasoundmeasuredoptic nerve sheath diameter (ONSD) combined with flash visual evoked potential (FVEP) in evaluating intracranial pressure of patients with craniocerebral injury. Methods The general data of 100 patients with craniocerebral injury admitted to the hospital from January 2020 to June 2022 were retrospectively analyzed. FVEP was used to detect the subjects’intracranial pressure. According to the use of ONSD, the subjects were divided into control group (n=43, without use of ONSD) and combination group (n=57, with ONSD). The use of dehydrating agents and the incidence of acute kidney injury (AKI) were compared between the groups.Discharge and recovery were recorded. ResultsIn this study, there were 51 patients with increased intracranial pressure and 49 patients with normal intracranial pressure.Patients with increased intracranial pressure in the two groups had similar intracranial pressure (P>0.05). In the combination group, patients with increased intracranial pressure had larger ONSD than those with normal intracranial pressure (P<0.05). The two groups had similar intracranial pressure (P>0.05). Correlation analysis showed that ONSD was positively correlatedintracranial pressure(P<0.05). The usage time and total dosage of mannitol in the combination group were significantly shorter/lower than those in the control group. Patients with AKI were fewer than the control group (P<0.05). The hospitalization cost and use intensity of antibiotics inthe combination group were lower than those in the control group. The length of hospital stay and mechanical ventilation time were significantly shorter than those of the control group (P<0.05). The cure rate inthe combination group was 66.67%, significantly higher than 44.19% inthe control group (P<0.05). ConclusionONSD combined with FVEP is of great significance for monitoring intracranial pressure of patients with craniocerebral injury, which also can guide clinical medication and promote recovery.