Objective:To investigate the value of myocardial contrast echocardiography ( MCE ) combined with serum γ-glutamyl transferase (γ-GT), fibroblast growth factor 21 (FGF21) and insulin-like growth factor-1 ( IGF-I ) in predicting the degree of coronary artery stenosis in patients with coronary heart disease.Methods: 68 patients with CHD admitted to our hospital from March 2020 to March 2022 were selected as the study group, and 68 patients with suspected coronary artery disease excluded by coronary angiography were selected as the control group. All subjects underwent selective coronary angiography (CAG), MCE and serum γ-GT, FGF21, IGF-I level detection.The differences of MCE quantitative parameters and serumγ-GT, FGF21 and IGF-I levels between the study group and the control group, as well as CHD patients with different stenosis degrees were compared by using the results of CAG as the gold standard for diagnosing the degree of coronary artery stenosis.The diagnostic efficacy of MCE, serum γ-GT, FGF21, IGF-I alone and in combination in the diagnosis of severe coronary artery stenosis in CHD patients was compared by drawing the receiver operating characteristic curve (ROC) and calculating the area under the curve (AUC).Results:The quantitative parameters of MCE (A value, β value and MBF value), serum FGF21 and IGF-I levels in the study group of patients with coronary heart disease were significantly lower than those in the control group (P<0.05), while the serum γ-GT level was significantly higher than that in the control group (P<0.05). <0.05). The MCE quantitative parameters (A value, β value and MBF value), serum FGF21 and IGF-I levels in the severe stenosis group in patients with coronary heart disease were significantly lower than those in the moderate stenosis group and mild stenosis group (P<0.05). The serum γ-GT level in the severe stenosis group was significantly higher than that in the moderate stenosis group and the mild stenosis group (P<0.05), and the moderate stenosis group was significantly higher than the mild stenosis group. degree of stenosis group (P<0.05). Compared with MCE, serum γ-GT, FGF21 and IGF-I alone, MCE combined with serum γ-GT, FGF21 and IGF-I to diagnose severe coronary stenosis in patients with coronary heart disease with AUC (0.918), sensitivity (93.48%) ) and the highest specificity (89.72%) (P<0.05).Conclusion: MCE combined with serum levels of γ-GT, FGF21, and IGF-I can help improve the diagnostic efficiency of severe coronary stenosis in patients with coronary heart disease, further guide the selection of clinical treatment options, and improve patient prognosis. Provide objective and real imaging and laboratory tests evidence.