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| 声动力疗法的机制研究进展 |
| 蒋恩琰,王丹,张照霞,王韫智,梁子彬,刘飞,陈磊,张梓宸,张潇键 |
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| (中山大学附属第五医院神经外科;中山大学附属第五医院胸部肿瘤科) |
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| 摘要: |
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| 关键词: 声动力疗法，空化效应，机械力，活性氧，钙超载 |
| DOI： |
| 投稿时间：2023-01-31修订日期：2023-02-12 |
| 基金项目:中国博士后科学基金面上项目(2020M683105)；国家自然科学基金(82172881)；广东省基础与应用基础研究基金(2019A1515011986)；广东省医学科学技术研究基金(A2019420)资助。 |
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| Research progress on mechanical mechanism of sonodynamic therapy |
| jiang enyan,wang dan,zhang zhaoxia,wang yunzhi,liang zibin,liu fei,chen lei,zhang zichen,zhang xiaojian |
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| Abstract: |
| Due to ultrasound-driven sonodynamic therapy has the advantages of non-invasiveness, targeting and tissue penetration, and significantly enhances the tumor treatment effect, it has a good application prospect in tumor prevention and treatment. At present, there is still a lack of overview of the effect of ultrasonic mechanical force in the mechanism research of sonodynamic therapy. Therefore, we review the current research progress of sonodynamic therapy in vivo and in vitro, integrate the mechanism of sonodynamic therapy in mechanical force, and provide readers with mechanistic force insights into the potential of sonodynamic therapy in cancer treatment. |
| Key words: Sonodynamic therapy Cavitation effect, Mechanical force, Reactive oxygen species, Calcium overload |
