| 摘要: |
| 外科治疗理念及科技的革新推动外科手术向微无创发展，近年来，涌现出多种微无创治疗方式；其中，组织摧毁术因具有非热损伤、非入侵式、刺激免疫系统等特点而被逐渐关注。组织摧毁术使用微秒至毫秒级的高峰值负压脉冲超声，使靶区瞬时产生空化泡，空化泡的膨胀和坍塌使靶区组织粉碎成亚细胞碎片；根据空化泡的产生方式，可分为空化云型和沸腾型组织摧毁术。目前，组织摧毁术已被广泛应用于前列腺增生、前列腺癌、肝肾肿瘤、骨肉瘤、胰腺癌、心血管病变、血栓等多种疾病。本文主要综述了组织摧毁术的原理、特点以及离体实验、动物研究和临床试验的最新结果。 |
| 关键词: 组织摧毁术，聚焦超声消融，作用原理，免疫效应 |
| DOI： |
| 投稿时间：2023-02-21修订日期：2023-09-02 |
| 基金项目:重庆市研究生科研创新项目（项目编号：CYS22375） |
|
| Mechanism and recent research on Histotripsy |
| liu hong,wang zhi biao,zhang cai |
| (State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, China.) |
| Abstract: |
| The innovation of surgical concepts and technology has promoted the development of surgical operations towards minimal- or non-invasiveness. In recent years, a variety of minimally- or non-invasive treatment methods have emerged, among which histotripsy is being noticed due to its characteristics of non-invasive, non-thermal ablation and stimulation of the immune system. Histotripsy typically uses microsecond to millisecond length ultrasound pulses with high peak negative pressure to instantly generate a cluster of cavitation bubbles in the target area and the expansion and collapse of the cavitation bubbles shatter the target tissue into subcellular fragments. According to the formation mode of cavitation bubbles, it can be divided into cavitation cloud histotripsy and boiling histotripsy. Nowadays, histotripsy has been applied in benign prostatic hyperplasia, prostate cancer, liver cancer, renal cancer, osteosarcoma, pancreatic cancer, cardiovascular diseases, thrombosis, and so on. This review provides an overview of histotripsy covering the mechanism, characteristics, and the latest research results on in-vitro experiments, animal studies, and clinical trials. |
| Key words: Histotripsy Focused ultrasound ablation Mechanism Immune effect |
