Objective：To explore the value of ultrasound-guided radiofrequency ablation combined with foam sclerosing agent in the treatment of great saphenous vein varices of different diameters and the short-term effect evaluation of ultrasound after operation.Methods：145 patients （145 affected limbs） with great saphenous vein varicose were selected from our hospital.According to the preoperative ultrasound measurement of the maximum diameter of the great saphenous vein thigh segment，they were divided into group A （98 cases）（diameter＜10 mm） and group B （47 cases）（diameter ≥ 10 mm）.Both groups were treated with ultrasound guided intracavitary radiofrequency ablation of the main great saphenous vein and foam sclerosing agent to treat superficial varicose veins of the lower leg. Compare the frequency of ablation and the occlusion rate of the great saphenous vein immediately, 1 month, and 6 months after surgery, residual lumen diameter, and postoperative complications between the two groups. Results：The average ablation frequency of each segment in Group B was greater than that in Group A, and the difference was statistically significant （P＜0.05）.The immediate occlusion rates of the great saphenous vein in Group A and Group B were 100%, and the occlusion rates of the great saphenous vein one month after surgery were 97.96% and 100%, respectively. The occlusion rates of the great saphenous vein six months after surgery were 95.92% and 95.74%, respectively. There was no statistically significant difference in the occlusion rates of the great saphenous vein between the two groups at different time points. At 1 month and 6 months after surgery, the residual lumen diameter of Group B was greater than that of Group A, and the difference was statistically significant（all P＜0.05）. There were no serious complications such as deep vein thrombosis or pulmonary embolism in both groups of patients after surgery, and there was no statistically significant difference in the proportion of subcutaneous ecchymosis and skin burns between the two groups; The proportion of subcutaneous cord stiffness veins in Group B was higher than that in Group A, and the difference was statistically significant （P＜0.05）.Conclusion：Ultrasound guided radiofrequency ablation combined with foam sclerosing agent has a high occlusion rate of great saphenous vein in the short term in the treatment of varices of great saphenous vein with different diameters. Ablation of great saphenous vein with larger diameters may require longer ablation cycles. Ultrasound plays an important role in intraoperative monitoring, postoperative follow-up and efficacy evaluation.