Objective To investigate the prognostic value of low-dose dobutamine stress echocardiography (LDDSE) combined with myocardial contrast echocardiography (MCE) in patients undergoing percutaneous coronary intervention (PCI). Methods A total of 32 patients with coronary heart disease who underwent PCI in the hospital from March 2020 to February 2021 were selected as the research subjects. All patients underwent LDDSE and MCE before PCI and at 3 months and 12 months after PCI. Perfusion of normal and necrotic myocardium was compared before and after operation. The patients were grouped according to the prognosis. Myocardial perfusion indicators were compared between patients with poor prognosis and patients with good prognosis at 3 months after PCI. The prognostic value of these indicators was analyzed. Results The A, β and A×β values measured by MCE alone and by LDDSE combined with MCE at the necrotic myocardium were lower than those of normal myocardium (P<0.05). The A, β and A×β values measured by MCE alone and by LDDSE combined with MCE at the necrotic myocardium at 3 months and 12 months after PCI were higher than those before PCI, and lower than those of normal myocardium (P<0.05). There was no statistically significant difference in A, β and A×β values measured by MCE alone and by LDDSE combined with MCE at 3 months and 12 months after PCI (P>0.05). After PCI, the A, β and A×β values measured by MCE alone and by LDDSE combined with MCE at the necrotic myocardium were lower in patients with poor prognosis than those with good prognosis (P<0.05). The receiver operating characteristic (ROC) curve analysis showed that the area under the curve (AUC) values of A, β and A×β values measured by MCE alone for prognosis were 0.682, 0.710 and 0.712. The AUC values of A, β and A×β values measured by LDDSE combined with MCE were 0.892, 0.853 and 0.801. Conclusion LDDSE combined with MCE can reflect myocardial microcirculation perfusion after PCI, and can be used for prognosis.