| 摘要: |
| 目的：探索青年焦虑人群的中医临床特点及颈动脉弹性变化。方法：收集于2022年5月-2022年9月就诊于东直门医院脑病科门诊的18-35岁青年人共78名作为研究对象，对其进行焦虑状态评估，并采用Esaote MyLab 90彩色多普勒超声仪，评估其颈动脉内中膜厚度及僵硬度。根据汉密尔顿焦虑量表（HAMA）分数，将研究对象分为焦虑组（≥14分）和不焦虑组（＜7分），分析两组人群的一般情况和颈动脉弹性各参数（颈动脉内中膜厚度QIMT、扩张系数DC、膨胀系数CC、α 僵硬度、β 僵硬度、脉搏波传导速度PWV）的差异。结果：两组间在量表学评分、颈动脉内中膜厚度及弹性各参数上均有统计学差异（P＜0.05）。焦虑组的PSQI评分及PSS评分均高于不焦虑组（P＜0.01），焦虑组的右侧颈动脉内中膜厚度大于不焦虑组（P＜0.05），焦虑组的颈动脉弹性较不焦虑组下降（P＜0.01）。HAMA分数与双侧DC、CC呈负相关，与双侧α、β、PWV呈正相关（P＜0.01）；在控制年龄、性别、身高、体重、BMI、血压、脉压差等相关因子后，HAMA分数与LCC呈负相关，与Lα、Lβ、LPWV呈正相关（P＜0.05），表明青年焦虑人群多具有失眠、压力大、颈动脉弹性差等特点，且随着焦虑程度的增加青年人颈动脉弹性逐渐变差。结论：在青年时期，还未发生动脉硬化之前，焦虑情绪对颈动脉就已经产生损伤，对于青年焦虑患者要注意疏解压力，改善睡眠，及时关注治疗有助于对血管的保护，延缓动脉硬化的发生发展。 |
| 关键词: 焦虑，颈动脉弹性，青年人群，动脉硬化 |
| DOI： |
| 投稿时间：2023-03-06修订日期：2023-04-22 |
| 基金项目:北京市科技计划课题——基于真实世界“毒损脑络”中风病复发关键环节诊断技术的优化研究(Z191100006619065)。 |
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| Correlation between anxiety and carotid artery elasticity in young adults |
| Wang Qiuyue,He Lili,Wang Yueqing,Yang Youcai,Wang Eryu,Li Na,Shan Beibei,Xie Yingzhen,Wang Xiangzhu |
| (Dongzhimen Hospital,Beijing University of Chinese Medicine Department of Ultrasound,the Third Affiliated Hospital of Beijing University of Chinese Medicine) |
| Abstract: |
| Objective: To explore the clinical characteristics of traditional Chinese medicine and changes in carotid artery elasticity in young people with anxiety. Method: A total of 78 young people aged 18-35 who visited the Department of Cerebrology at Dongzhimen Hospital from May 2022 to September 2022 were collected as research subjects. Their anxiety status was evaluated, and their carotid intima media thickness and stiffness were evaluated using Esaote MyLab 90 color Doppler ultrasound. According to the Hamilton Anxiety Scale (HAMA) scores, the study subjects were divided into an anxiety group (≥14 points) and a non anxiety group (<7 points). Analyze the general situation, traditional Chinese medicine symptoms, and differences in various parameters of carotid artery elasticity(Carotid artery intima-media thickness QIMT, dilation coefficient DC、dilation coefficient CC、αStiffness、βStiffness、pulse wave conduction velocity) between the two groups of people. Result: There were statistical differences between the two groups in terms of scale scores, carotid intima media thickness, and elasticity parameters (P<0.05). The PSQI and PSS scores of the anxiety group were higher than those of the non anxiety group (P<0.01). The thickness of the right carotid artery intima media in the anxiety group was greater than that in the non anxiety group (P<0.05), and the carotid artery elasticity in the anxiety group decreased compared to the non anxiety group (P<0.01). HAMA score is negatively correlated with bilateral DC and CC, and is correlated with bilateral α、β、 PWV showed a positive correlation (P<0.01); After controlling for related factors such as age, gender, height, weight, BMI, blood pressure, and pulse pressure difference, the HAMA score was negatively correlated with LCC and was negatively correlated with Lα、Lβ、LPWV shows a positive correlation (P<0.05), indicating that young people with anxiety tend to have characteristics such as insomnia, high stress, and poor carotid artery elasticity. As the level of anxiety increases, the carotid artery elasticity of young people gradually deteriorates. There is a statistically significant difference in traditional Chinese medicine symptoms between the two groups (P<0.05). This indicates that young people with anxiety often have characteristics such as insomnia, high stress, and poor carotid elasticity, and as the level of anxiety increases, the carotid elasticity of young people gradually deteriorates. Conclusion: In youth, before arteriosclerosis occurs, anxiety can cause damage to the carotid artery. For young anxiety patients, it is important to relieve stress, improve sleep, and pay timely attention to treatment to protect blood vessels and delay the occurrence and development of arteriosclerosis. |
| Key words: anxiety, carotid artery elasticity, youth population, arteriosclerosis |
