[Abstract] Objective：To compare the enhancement features of Sonazoid and SonoVue CEUS (contrast-enhanced ultrasound, CEUS) in renal clear cell carcinoma, and compare them with CECT (contrast-enhanced computed tomography, CECT) , to explore the application value of different ultrasound contrast agents and examination methods in the diagnosis of renal clear cell carcinoma. Methods: 47 patients with renal clear cell carcinoma (47 lesions in total) who were diagnosed pathologically in our hospital from June 2020 to September 2022 were selected as the study subjects. All patients underwent CEUS and CECT examinations. According to the different types of ultrasound contrast agents selected, the patients were divided into SonoVue group (21 cases) and Sonazoid group (26 cases). Observe the enhancement characteristics of the lesions in the two groups and compare them with CECT.Results:1. Sonazoid-CEUS and SonoVue-CEUS showed no significant difference in the enhancement mode, peak intensity, and enhancement uniformity of renal clear cell carcinoma between the two groups (P>0.05).2. Comparison of CEUS and CECT enhancement features: The peak intensity of CEUS and CECT in 47 cases of renal clear cell carcinoma was mainly rich in blood supply, which was (42/47, 89.36%) and (40/47, 85.11%), respectively, with no significant difference (P>0.05); In CEUS, the proportion of homogeneous diffuse enhancement at the peak of the lesions was significantly higher than that in CECT, which was (12/47, 25.53%) and (4/47, 8.51%) respectively, and the difference was statistically significant (P<0.05); CEUS showed that the enhancement mode of focus was fast forward in 35 cases (35/47) and fast backward in 42 cases (42/47). Compared with the results of CECT, there was no significant difference between the two (P>0.05). Conclusion; Sonazoid is equally suitable for contrast-enhanced ultrasound of kidney. Like SonoVue-CEUS and CECT, it can well reflect the blood perfusion characteristics of renal clear cell carcinoma, and they can complement each other to provide more valuable information for the diagnosis of renal clear cell carcinoma.