| 摘要: |
| 目的 分析腹部超声造影检查静脉注射六氟化硫微泡后的安全性。方法 回顾性分析2006年1月到2021年9月在本中心进行的所有静脉注射六氟化硫微泡行腹部超声造影检查的患者。收集发生不良反应的患者基本信息、症状和体征,总结不良反应的类型和严重程度,分析发生不良反应的危险因素。结果 91312次静脉注射六氟化硫微泡超声造影检查中,35例(0.038%)发生不同程度不良反应,其中男25例,女10例,轻度18例、中度10例、重度7例,无死亡病例发生。不良反应症状包括过敏样反应7例,类生理反应28例。过敏样反应中,最常见是局部荨麻疹、瘙痒。类生理反应中,最常见是恶心、呕吐及血管迷走神经反应。65.7%(23/35)不良反应患者年龄段为40～60岁。31例患者有不同程度的肝功能异常(88.6%)。1例有磺胺类药物过敏史。34例不良反应发生在注射造影剂后10min内(97.1%),所有患者症状均在当日缓解。轻度不良反应患者中,12例休息后缓解,6例接受治疗后缓解；中度、重度不良反应患者全部接受治疗后缓解。结论 腹部超声造影检查中静脉注射六氟化硫微泡后发生不良反应的频率是非常低的,具有极高的临床应用安全性。 |
| 关键词: 腹部超声 造影剂 不良反应 |
| DOI： |
| 投稿时间：2023-03-07修订日期：2023-03-21 |
| 基金项目:国家自然科学基金面上项目(82171956) |
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| Safety analysis of intravenous sulfur hexafluoride microbubble in abdominal ultrasonography |
| tanyingyue |
| () |
| Abstract: |
| Objective To analyze the safety of abdominal contrast-enhanced ultrasound (CEUS) after intravenous injection of sulfur hexafluoride microbubbles. Methods All patients who underwent abdominal CEUS examination with intravenous injection of sulfur hexafluoride microbubbles in our center from January 2006 to September 2021 were retrospectively analyzed. The basic information, symptoms and signs of patients with adverse events(AEs) were collected, and the types, severity and risk factors of AEs were summarized. Results A total of 91312 intravenous injections of sulfur hexafluoride microbubbles were enrolled and 35 cases (0.038%) had AEs, including 25 males and 10 females. A total of 18 cases were mild, 10 moderate and 7 severe in severity, and no death occurred. There were 7 allergy-like AEs and 28 physiologic AEs. For patients with allergy-like AEs,the most common sign and symptom was limited urticaria/pruritis. For patients with physiologic AEs, the most common signs and symptoms were nausea/vomiting and vasovagal reactions. The most common age of the AEs were 40~60 years old (65.7%, 23/35).Thirty-one (88.6%) patients had abnormal liver function. Only one has a history of sulfa drug allergy. Almost all patients with AEs (97.1%, 34/35) occurred within 10 minutes after contrast agent injection, and all patients were recovered on the same day. Among the patients with mild AEs, 12 were relieved without any treatment and 6 were relieved after receiving corresponding treatment. All the patients with moderate and severe AEs were relieved after receiving corresponding treatment. Conclusion The incidence of adverse events after intravenous injection of sulfur hexafluoride microbubbles in abdominal CEUS is very low, which has a high safety in clinical application. |
| Key words: Abdominal contrast-enhanced ultrasound Contrast agent Adverse events |
