| 摘要: |
| 目的 探讨颈动脉超声联合ABCD3-Ⅰ评分及血清微小RNA-146a(miR-146a)对短暂性脑缺血发作(TIA)后继发脑梗死(CI)的预测价值。方法 选取2020年1月~2022年12月我院收治的90例TIA患者,根据TIA后30天内是否继发CI分为CI组42例和非CI组48例。比较各组临床资料及入院时的颈动脉狭窄程度、ABCD3-Ⅰ评分和血清miR-146a水平；分析CI组颈动脉狭窄程度、ABCD3-Ⅰ评分和血清miR-146a的相关性；Logistic回归分析影响TIA后继发CI的危险因素,受试者工作特征曲线(ROC)检测ABCD3-Ⅰ评分、颈动脉狭窄程度和血清miR-146a对TIA后继发CI的预测效能。结果 CI组重度颈动脉狭窄率、ABCD3-Ⅰ评分和血清miR-146a均明显高于非CI组(P＜0.05)；Spearman相关性分析,ABCD3-Ⅰ评分、血清miR-146a与不同颈动脉狭窄程度呈正相关(P＜0.05)；Pearson相关性分析,ABCD3-Ⅰ评分与血清miR-146a呈正相关(P＜0.05)；Logistic回归分析,年龄、3个月内TIA发作次数≥3、重度颈动脉狭窄、ABCD3-Ⅰ评分≥8.33分和血清miR-146a≥1.79均为影响TIA后继发CI的独立危险因素(P＜0.05)；ROC分析,颈动脉狭窄程度、血清miR-146a和ABCD3-Ⅰ评分预测TIA后继发CI的曲线下面积(AUC)分别为0.820、0.889和0.854。结论 颈动脉超声、ABCD3-Ⅰ评分和血清miR-146a对TIA后继发CI均具有较好的预测效能,其中血清miR-146a的预测效能最佳。 |
| 关键词: 颈动脉超声 ABCD3-Ⅰ评分 miR-146a 短暂性脑缺血发作 继发脑梗死 预测效能 |
| DOI： |
| 投稿时间：2023-03-21修订日期：2023-06-21 |
| 基金项目: |
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| Predictive value of carotid ultrasound combined with ABCD3-I score and serum miR-146a for secondary cerebral infarction after TIA |
| pengxiaolei,yixiaorong,wangyin,yangyanxing,haojieni |
| () |
| Abstract: |
| Objective To explore the predictive value of carotid ultrasound combined with ABCD3-I score and serum microRNA-146a (miR-146a) for secondary cerebral infarction (CI) after transient ischemic attack (TIA). Methods A total of 90 patients with TIA admitted to the hospital were enrolled between January 2020 and December 2022. According to presence or absence of secondary CI within 30d after TIA, they were divided into CI group (42 cases) and non-CI group (48 cases). The clinical data, severity of carotid stenosis, ABCD3-I score and serum miR-146a at admission in different groups were compared. The correlation among the severity of carotid stenosis, ABCD3-I score and serum miR-146a in CI group was analyzed. The risk factors of secondary CI after TIA were analyzed by Logistic regression analysis. The predictive efficiency of ABCD3-I score, carotid stenosis and serum miR-146a for secondary CI was detected by receiver operating characteristic (ROC) curves. Results The severe carotid stenosis rate, ABCD3-I score and serum miR-146a in CI group were significantly higher than those in non-CI group (P<0.05). Spearman correlation analysis showed that ABCD3-I score and serum miR-146a were positively correlated with the severity of carotid stenosis (P<0.05). Pearson correlation analysis showed that ABCD3-I score was positively correlated with serum miR-146a (P<0.05). Logistic regression analysis showed that age, TIA attacks ≥3 times within 3 months, severe carotid stenosis, ABCD3-I score ≥8.33 points and serum miR-146a ≥1.79 were independent risk factors of secondary CI after TIA (P<0.05). ROC curves analysis showed that the area under the curve (AUC) values of carotid stenosis severity, serum miR-146a and ABCD3-I score for predicting secondary CI were 0.820, 0.889 and 0.854, respectively. Conclusion Carotid ultrasound, ABCD3-I score and serum miR-146a all have good predictive efficiency for secondary CI after TIA, and serum miR-146a has the highest predictive efficiency. |
| Key words: Carotid ultrasound ABCD3-I score MiR-146a Transient ischemic attack Secondary cerebral infarction Predictive efficiency |
