Objective: To explore the value of salivary gland ultrasound score combined with elastography in evaluating disease activity of sjogren syndrome (SS). Methods:A total of 80 cases of SS diagnosed and treated in the outpatient department or ward of Rheumatology in our hospital were collected. All patients met the classification criteria of American College of Rheumatology (ACR)/ European League Against Rheumatism (EULAR) in 2016. Patients were divided into disease activity group and stable group according to Eular Sjogren's syndrome disease activity index (ESSDAI). The parotid and submandibular glands of the patients in the two groups were scored with 0-4 ultrasound and examined with elastography. The receiver operating characteristic curve (ROC) of the two methods and their combination were drawn and the area under curve (AUC) was calculated to compare their evaluation values. Results: The area under ROC curve of using ultrasound score alone to judge disease activity of SS was 0.668. The areas under the ROC curve of using elastography of parotid gland and submandibular gland alone to judge the disease activity of SS were 0.774 and 0.692, respectively. The area under the ROC curve for the combined use of the two methods to assess disease activity in SS was 0.828, giving a sensitivity of 81.3% and a specificity of 81.2%. Conclusion: The salivary gland ultrasonic scoring system combined with elastography is helpful for the evaluation of SS in different disease activities.