| 摘要: |
| 目的 分析不同年龄段肝豆状核变性(Wilson’s disease,WD)患者肝损害的超声声像图特点, 以期寻得该病肝损害的规律及相应超声特征,为临床诊断及治疗提供依据。方法? 回顾性分析2018年9月至2022年08月在四川大学华西第四医院超声科进行腹部超声检查的WD患者247例。根据年龄大小将患者分为三组:未成年人组(≤17岁)、青年组(18~44岁)及中老年组(≥45岁)。将所观察到的声像图分为四组:A组 脂肪肝声像图,B组 肝纤维化或早期肝硬化声像图,C组 晚期肝硬化(伴或不伴门静脉高压)声像图,D组 正常肝脏超声声像图。由两位医师进行读图分类。结果? 1、两位医师读图分类一致性程度较强。2、247例WD患者主要为未成年人及青年人(227,91.90%)。3、WD患者肝损害超声表现主要为B组肝损害(108,43.72%)及C组肝损害(102,41.30%)。4、未成年组、青年组与中老年组三组间的肝损害分布差异具有统计学意义(P<0.05)。青年组与中老年组以B组及C组肝损害超声表现为主,两者占比接近,其中C组肝损害显著高于未成年组。未成年组以A组及B组肝损害为主,其中A组肝损害显著高于青年组及中老年组。结论? 不同年龄段的肝豆状核变性患者肝损害超声表现具有一定的特征性,且随着年龄增加,其肝损害程度逐渐加重。 |
| 关键词: 肝豆状核变性,年龄,肝损害,超声表现 |
| DOI： |
| 投稿时间：2023-05-10修订日期：2023-12-04 |
| 基金项目:四川省医学科研课题计划（编号S21110） |
|
| Ultrasound findings of liver damage in different age groups of Wilson’s disease |
| TANG Yali,LING Wenwu |
| (West China Fourth Hospital，Sichuan University;West China Hospital，Sichuan University) |
| Abstract: |
| Objective To analyze the ultrasound findings of liver damage in patients of Wilson’s disease at different ages, In order to find out the law of liver damage and the corresponding ultrasound characteristics of this disease, so as to provide a basis for clinical diagnosis and treatment..Methods A total of 247 WD patients who underwent abdominal ultrasound examination in the Department of Ultrasound Medicine, West China Fourth Hospital,Sichuan University from September 2018 to August 2022 were collected.The patients were divided into three groups according to age: minor group (≤17 years old), youth group (18-44 years old), middle-old-aged group (≥45 years old).According to the ultrasound images, the patients were divided into four groups: group A fatty liver images, group B liver fibrosis or early liver cirrhosis images, group C advanced liver cirrhosis (with or without portal hypertension), and group D normal liver images.Two doctors were arranged to do the image classification. Results? 1.The classification consistency between the two doctors was strong.2.247 WD patients were mainly minors and youth(227, 91.90%).3.Liver damage was mainly composed of liver damage in group B (108,43.72%) and group C (102,41.30%).4.There were statistically significant differences in the distribution of liver damage among the three groups: the minor group, the youth group and the middle-old-aged group(P<0.05). The liver damage in the youth group and the middle-old-aged group was mainly in group B and? group C, the proportion of the two groups was close, and the liver damage in group C was significantly higher than that in the minor group.? The liver damage in the minor group was mainly in group A and group B, and the liver damage in group A was significantly higher than that in the youth group and the middle-old-aged group.Conclusion The ultrasonic images of liver damage in WD patients of different ages have certain characteristics, and the degree of liver damage increases gradually with the increase of age. |
| Key words: Wilson’s disease, age, liver damage,ultrasound findings |
