Purpose: Trauma is the main leading cause of disability and death in young adult population, of which blunt abdominal trauma is one of the most common types of injury, rapid identification of organ injury in blunt abdominal trauma patients is crucial. The purpose of this study was to evaluate the diagnostic ability of contrast-enhanced ultrasound (CEUS) in adults with blunt abdominal trauma. Methods: Patients with blunt abdominal trauma attending the emergency department of the Second Hospital of Chongqing Medical University from 2020.10 to 2023.2 were included in this study, general demographic and injuries procedure were collected, organ injuries were assessed by comparing the results of enhanced computed tomography (CECT) and CEUS with American Association for Trauma Surgery standards. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of CEUS were calculated by drawing cross-tabulations using CECT as a standard.The diagnostic performance between CEUS and CECT were compared by McNemar-Bowke test. The diagnostic consistency between CEUS and CECT was analyzed by kappa consistency test, the cost differences were compared by rank sum test, and the adverse reactions of CEUS were reported. Results: A total of 42 patients with blunt abdominal trauma were included, predominantly male patients. 30 injury patients were found by CECT and 29 injury patients were found by CEUS, and the sensitivity of CEUS was found to be 93.33%, specificity 91.67%, positive predictive value 96.55%, negative predictive value 84.62%, and diagnostic accuracy 92.86%, respectively. McNemar-Bowke test showed that there was no statistical difference in diagnostic performance between CEUS and CECT (χ2=1,P=0.317). Kappa consistency test found that its Kappa value was 0.966. No adverse events were observed and the single time cost was significantly lower than that of CECT (￥806 vs. ￥1657,P=0.000). Conclusion: CEUS is a safe, effective, convenient, low-cost, and radiation-free imaging method that can be used as an effective alternative method to CECT in blunt abdominal trauma patients.