| 摘要: |
| 目的:探讨多模态超声参数对老年肌少症的诊断及其在治疗效果中的评价。方法:选取2019年8月至2022年3月诊治的84例老年肌少症患者作为研究对象,并设立为观察组,同期选取42例健康老年人作为对照组,均予以超声检查,对比肌肉厚度、羽状角、肌束长度及放松、收缩状态下杨氏模量,观察常规西药和弹力带训练后的总有效率及入院时、干预1、3、6个月的握力、ASMI、SPPB评分；并采用ROC曲线模型分析肌肉厚度、羽状角、肌束长度及杨氏模量诊断肌少症和预测疗效的AUC值、敏感度及特异度。结果:观察组的肌肉厚度、羽状角、肌束长度均低于对照组(P＜0.05)。观察组放松状态、收缩状态的杨氏模量均低于对照组(P＜0.05)。诊断效能:肌肉厚度、羽状角、肌束长度、杨氏模量及多模态超声综合参数诊断肌少症的AUC值分别为(0.775、0.716、0.621、0.749、0.911,P＜0.05)。84例老年肌少症经治疗后总有效率86.90%,其中,显效占44例(52.38%),有效占29例(34.52%),无效占11例(13.09%),且干预1、3、6个月的握力、ASMI、SPPB评分均高于入院时(P＜0.05)。预测效能:肌肉厚度、羽状角、肌束长度、杨氏模量预测肌少症疗效的AUC值分别为(0.805、0.846、0.785、0.775,P＜0.05)。结论:多模态超声参数在老年肌少症诊断中具有较高的临床价值,同时也能为肌少症治疗效果评估提供客观指导。 |
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| DOI： |
| 投稿时间：2023-06-06修订日期：2023-07-03 |
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| Diagnosis of senile sarcopenia by multimodal ultrasound parameters and evaluation of its therapeutic effect |
| Liu Wei,Zhang Jianlei,Liu Yu,Cao Guangming,Jing Lei |
| () |
| Abstract: |
| Objective: To investigate the diagnosis of senile sarcopenia by multi-modal ultrasound parameters and its therapeutic effect. Method: Eighty-four senile patients with sarcopenia diagnosed and treated from August 2019 to March 2022 were selected as the study object and set as the observation group, while 42 healthy elderly patients were selected as the control group during the same period. Ultrasonography was performed to compare the muscle thickness, pinniform Angle, muscle bundle length and Young"s modulus under relaxed and contracted conditions. The total effective rate after routine western medicine and elastic band training was observed, and the score of grip strength, ASMI and SPPB at admission, 1, 3 and 6 months after intervention. The AUC value, sensitivity and specificity of muscle thickness, pinniate Angle, muscle bundle length and Young"s modulus in diagnosing sarcopenia and predicting curative effect were analyzed by ROC curve model. Results: The muscle thickness, pinniate Angle and muscle bundle length in observation group were lower than those in control group (P < 0.05). Young"s modulus of relaxation and contraction in observation group were lower than those in control group (P < 0.05). Diagnostic efficacy: The AUC values of muscle thickness, pinniform Angle, muscle bundle length, Young"s modulus and multimodal ultrasonic parameters for diagnosing sarcopenia were 0.775, 0.716, 0.621, 0.749, 0.911, P < 0.05, respectively. The total effective rate of 84 cases of senile sarcopenia after treatment was 86.90%, of which 44 cases (52.38%) were significantly effective, 29 cases (34.52%) were effective, and 11 cases (13.09%) were ineffective. The grip strength, ASMI and SPPB scores at 1, 3 and 6 months after intervention were higher than those at admission (P < 0.05). Predictive efficacy: The AUC values of muscle thickness, pinniate Angle, muscle bundle length and Young"s modulus for predicting the efficacy of sarcopenia were 0.805, 0.846, 0.785, 0.775, P < 0.05. Conclusion: Multi-modal ultrasound parameters have high clinical value in the diagnosis of senile sarcopenia, and can also provide objective guidance for the evaluation of the treatment effect of sarcopenia. |
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