| 摘要: |
| 目的 探讨脑梗死后遗症期视网膜中央动脉（CRA）的血流特征，分析其与血管性认知障碍（VCI）的相关性。方法 纳入脑梗死后遗症期患者95例为病例组，健康志愿者77例为对照组。采用简易精神状态量表（MMSE）评价受试者认知功能并根据分为轻度认知障碍（MCI）和血管性痴呆（VaD）。应用平面波超敏感血流显像技术（Angio PLUS）检测CRA血流参数，包括收缩期峰值血流速度（PSV）、舒张末期血流速度（EDV）、阻力指数（RI）及搏动指数（PI），比较两组各CRA血流参数及临床资料的差异。采用二元Logistic回归分析脑梗死的危险因素；Spearman秩相关系数评价CRA血流参数与是否发生VCI、VCI分度的相关性。结果 病例组与对照组糖尿病、高血压占比及BMI比较，差异均有统计学意义（均P＜0.05）。二元Logistic回归分析，结果显示高血压、糖尿病、BMI均为脑梗死的独立危险因素（均P＜0.05）。病例组与对照组PSV、EDV、RI、PI比较，差异均有统计学意义（均P＜0.05）；病例组中VaD患者EDV较MCI患者减小，RI、PI均较MCI患者增高，差异均有统计学意义（均P＜0.05）；对照组和病例组中有无脑梗死危险因素（高血压、糖尿病、BMI异常）者CRA各血流参数比较，差异均无统计学意义；病例组患侧与健侧各CRA血流参数比较，差异均无统计学意义。相关性分析显示，是否发生VCI与PSV、EDV均呈负相关（r=-0.237、-0.477，均P＜0.01），与RI、PI均呈正相关（r=0.459、0.450，均P＜0.01）；病例组VCI分度与EDV呈负相关（r=-0.240，P=0.020），与RI、PI均呈正相关（r=0.213、0.209，均P＜0.01）。结论 CRA在脑梗死后遗症期中存在一定血流特征，且CRA与VCI存在一定相关性，CRA可能是VCI深入研究的潜在生物学标志物。 |
| 关键词: 脑梗死 视网膜中央动脉 血管性认知障碍 血流动力学 超声 |
| DOI： |
| 投稿时间：2023-08-25修订日期：2024-03-14 |
| 基金项目:川北医学院揭榜挂帅项目（2022JB001） |
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| Central retinal artery blood flow characteristics and its correlation with vascular cognitive impairment in the postcerebral infarction period |
| Chen Yaping,Liu Tingqiong,Li Yu,Dan Siyu,Yue Wensheng,Jiang Guohui |
| () |
| Abstract: |
| Objective To investigate the blood flow characteristics of the central retinal artery（CRA） in the postcerebral infarction phase. And to analysis its correlation with vascular cognitive impairment (VCI).Methods Ninety-five patients with sequelae of cerebral infarction were included as a case group，and 77 healthy volunteers were included as a control group.The subjects'' cognitive functions（categorized according to the scores： mild coginitive impairment（MCI） and dementia（VaD） were evaluated using the Brief Mental State Examination（MMSE）.Plane wave ultrasensitive flow imaging（Angio PLUS） was applied to explore each flow parameter of CRA，and the flow characteristics and differences of CRA in the case and control groups were analyzed.The correlation between CRA and VCI was analyzed according to whether the patients developed VCI and VCI grades.Results There was no statistically significant difference in age，gender，education level，hyperlipidemia，smoking and alcohol consumption between the two groups（all P>0.05），the difference in diabetes，hypertension and BMI was statistically significant（all P＜0.05）.Correlation analysis showed that there was a significant correlation between each blood flow parameter of CRA and whether or not VCI occurred and VCI score，which was positively correlated.The VCI score was negatively correlated with the EDV in the case group（r=-0.240，P=0.020） and negatively correlated with the RI（r =0.213，P＜0.05）.Conclusion CRA has certain blood flow characteristics in the postinfarction phase of cerebral infarction. And there is some correlation between CRA and VCI CRA may be a potential biomarker for intensive VCI research. |
| Key words: Cerebral infarction Central retinal artery Vascular cognitive impairment Hemodynamics Ultrasound |
