Objective To establish a nomogram model for predicting stress urinary incontinence (SUI) in puerperal women based on pelvic floor ultrasound parameters, matrix metalloproteinase-1 (MMP-1), osteopontin (OPN) and connective tissue growth factor (CTGF).Method The clinical data of 148 primiparas admitted from January 2021 to January 2023 were retrospectively analyzed. According to whether SUI occurred 3 months postpartum, they were divided into SUI group (37 cases) and non-SUI group (111 cases). Unifactor analysis and multiple Logistic regression were used to analyze the influencing factors of SUI in primipara. A nomogram model was constructed, and receiver operating characteristic curve (ROC curve) was used to analyze the predictive value of this model.Result Multivariate Logistic regression analysis showed that Pelvic floor ultrasound parameters [urethral rotation Angle (URA), urethral inclination Angle (UTA), bladder neck mobility (BND), vesicourethral posterior Angle (PUA), anal extraction and anal fissure area (LHA)] and serum MMP-1, OPN and CTGF were independent risk factors for SUI in parturient women (P<0.05). The AUC of the column-line diagram model constructed based on the above eight indexes was 0.920, and the sensitivity and specificity were 100.0% and 92.0%, which were all higher than each single index in the model, and the column-line diagram model was well fitted (Hosmer-Lemeshow x2=82.349,P=0.642).Conclusion URA, UTA, BND, PUA, LHA, MMP-1, OPN, and CTGF are all independent predictors of SUI in primipara. The nomogram model established based on the above 8 indicators has high predictive value for SUI in primipara, and can provide theoretical basis for the prevention and treatment of SUI in primipara.