Objective : To investigate the effect of acquired thrombophilia on fetal cardiac morphology and systolic function. Methods : A total of 24 pregnant women diagnosed with acquired thrombophilia (case group) and 40 healthy pregnant women (control group) who visited the Affiliated Hospital of North Sichuan Medical College from February 2022 to February 2023 were selected. The general clinical charicteristics , Fetal growth indexes and placental Doppler blood flow parameters of the two groups of pregnant women were collected. Fetal HQ quantitative analysis techniques were used to measure fetal heart morphology and ventricular function, including whole-heart global spherical index (GSI), left and right ventricular global longitudinal strain (GLS), area change fraction (FAC) and free wall strain (FWS),Left ventricular septal wall strain(SWS) and left ventricular ejection Fraction (EF),The correlation between fetal HQ functional parameters and placental Doppler blood flow parameters was examined using Pearson correlation analysis.Results: There was no significant difference in GSI between the two groups (P > 0.05). Fetal systolic function parameters:left ventricular EF,GLS, FAC, FWS and SWS were not significantly different (all P > 0.05). Fetal right ventricular GLS, FAC and FWS were lower than those in control group(all P < 0.05),The correlation analysis revealed a positive association between the S/D value of the fetal umbilical artery and right ventricular GLS, as a negative association with right ventricular FAC. Conclusions: Acquired thrombophilia may lead to fetal right ventricular systolic dysfunction, which may be related to placental dysfunction.