| 摘要: |
| 目的:探讨获得性易栓症对胎儿心脏形态和收缩功能的影响。方法: 选取2022年2月至2023年2月在川北医学院附属医院就诊并确诊为获得性易栓症孕妇24例（病例组）和同期就诊的健康孕妇40例（对照组）。收集两组孕妇的一般临床资料、胎儿生长值、胎盘多普勒血流参数，应用Fetal HQ定量分析技术测量两组胎儿心脏形态和心室功能，包括全心整体球形指数（GSI）和左、右心室整体纵向应变（GLS）、面积变化分数（FAC）、游离壁应变（FWS），左室间隔壁应变（SWS）及左室射血分数（EF），利用Pearson相关分析法分析Fetal HQ功能参数与胎盘多普勒血流参数的相关性。结果:两组胎儿心脏形态参数全心GSI比较，差异无统计学意义（P＞0.05）。两组胎儿心脏收缩功能参数左室EF、GLS、FAC、FWS、SWS比较，差异均无统计学意义(均P＞0.05)。病例组胎儿右室GLS、FAC、FWS较对照组低(均P＜0.05)，相关分析显示病例组胎儿脐动脉S/D值与右室GLS呈正相关与右室FAC呈负相关(均P＜0.05)。结论:获得性易栓症可导致胎儿右室收缩功能受损，损伤原因可能与胎盘功能障碍有关。 |
| 关键词: 获得性易栓症 胎儿心脏定量分析 心功能 应变 面积变化分数 |
| DOI： |
| 投稿时间：2023-09-09修订日期：2023-09-25 |
| 基金项目: |
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| Evaluation of fetal cardiac morphology and function in pregnant women with acquired thrombophilia using Quantitative fetal heart software |
| TANG Xiao Qin,WANG Wan,LI Rui |
| (Affiliated Hospital of North Sichuan Medical College) |
| Abstract: |
| Objective : To investigate the effect of acquired thrombophilia on fetal cardiac morphology and systolic function. Methods : A total of 24 pregnant women diagnosed with acquired thrombophilia (case group) and 40 healthy pregnant women (control group) who visited the Affiliated Hospital of North Sichuan Medical College from February 2022 to February 2023 were selected. The general clinical charicteristics , Fetal growth indexes and placental Doppler blood flow parameters of the two groups of pregnant women were collected. Fetal HQ quantitative analysis techniques were used to measure fetal heart morphology and ventricular function, including whole-heart global spherical index (GSI), left and right ventricular global longitudinal strain (GLS), area change fraction (FAC) and free wall strain (FWS),Left ventricular septal wall strain(SWS) and left ventricular ejection Fraction (EF),The correlation between fetal HQ functional parameters and placental Doppler blood flow parameters was examined using Pearson correlation analysis.Results: There was no significant difference in GSI between the two groups (P > 0.05). Fetal systolic function parameters:left ventricular EF,GLS, FAC, FWS and SWS were not significantly different (all P > 0.05). Fetal right ventricular GLS, FAC and FWS were lower than those in control group(all P < 0.05),The correlation analysis revealed a positive association between the S/D value of the fetal umbilical artery and right ventricular GLS, as a negative association with right ventricular FAC. Conclusions: Acquired thrombophilia may lead to fetal right ventricular systolic dysfunction, which may be related to placental dysfunction. |
| Key words: Acquired thrombophilia fetal heart quantification Cardiac function Strain Fractional area change |
