| 摘要: |
| 目的 探讨合并桥本氏甲状腺炎（HT）对甲状腺结节超声引导下细针穿刺细胞学检查（US-FNAC）诊断效能的影响。方法 回顾性收集于我院行US-FNAC及外科切除手术的1159例甲状腺结节患者（共1383个结节）病历资料，根据其是否合并HT分为HT+组456个结节和HT-组927个结节，以手术病理结果为金标准，计算比较US-FNAC诊断两组结节的诊断效能。结果 US-FNAC诊断HT+组结节的灵敏度、阴性预测值、准确率（96.0%、40.7%、94.3%）均低于HT-组（98.8%、73.0%、97.1%），假阴性率（4.0%）高于HT-组（1.2%），差异均有统计学意义（均P＜0.05）。进一步分析显示，US-FNAC诊断HT+组最大径≤10 mm结节的灵敏度、阳性预测值、准确率（96.2%、97.5%、94.0%）均低于HT-组（98.8%、99.3%、98.2%），假阴性率（3.8%）高于HT-组（1.2%），差异均有统计学意义（均P＜0.05）；US-FNAC诊断两组最大径＞10 mm结节的各项指标比较差异均无统计学意义。结论 对于最大径≤10 mm的甲状腺结节，合并HT可降低US-FNAC的诊断效能。 |
| 关键词: 超声引导 细针穿刺细胞学检查 桥本氏甲状腺炎 甲状腺结节 BRAF基因 |
| DOI： |
| 投稿时间：2023-10-12修订日期：2024-06-08 |
| 基金项目: |
|
| The impact of presence of Hashimoto’s thyroiditis on the diagnostic efficacy of ultrasound-guided fine-needle aspiration cytology for thyroid nodules |
| caiyundan,liyanming,tangxiuwen,zhengyaunyi |
| () |
| Abstract: |
| Objective To investigate the influence of combined Hashimoto''s thyroiditis（HT） on the diagnostic accuracy of ultrasound-guided fine-needle aspiration cytology（US-FNAC） for thyroid nodules.Methods The medical records of 1159 patients (a total of 1383 nodules) with thyroid nodules who underwent US-FNAC and subsequent surgical resection in our hospital were collected. Based on the presence of HT, the nodules were divided into HT+ group (456 nodules) and HT- group (927 nodules). The diagnostic performance of US-FNAC for both groups was compared using surgical pathology as the gold standard. Results The sensitivity, negative predictive value, and accuracy of US-FNAC for HT+ group nodules (96.0%、40.7%、94.3%) were all lower than those for HT- group nodules (98.8%、73.0%、97.1%), and the false-negative rate (4.0%) was higher than that of the HT- group (1.2%), with all differences being statistically significant (P＜0.05). Further analysis showed that for nodules with a maximum diameter ≤10mm, the sensitivity, positive predictive value, and accuracy of US-FNAC for HT+ group (96.2%、97.5%、94.0%) were all lower than those for HT- group (98.8%、99.3%、98.2%), and the false-negative rate (3.8%) was higher than that of the HT- group (1.2%), with all differences being statistically significant (P＜0.05). For nodules with a maximum diameter ＞10mm, there were no statistically significant differences between the two groups. |
| Key words: ultrasound-guided fine-needle aspiration cytology Hashimoto’s thyroiditis thyroid nodule BRAF gene |
