Objective To explore the ultrasound sonographic features of liposarcoma. Methods We retrospectively analyzed the data and ultrasound sonographic features of 31 patients with pathologically confirmed liposarcoma by surgical resection at our institution. Results Among the 31 patients, there were 13 cases of dedifferentiated liposarcoma, 10 cases of well-differentiated liposarcoma, 4 cases of pleomorphic liposarcoma, and 4 cases of myxoid liposarcoma, the average maximum diameter of the tumors was about (16.97±9.70) cm. The lesions were predominantly iso-hyper-echoic in 61.3% (19/31), with heterogeneous distribution of the echoes in 90.3% (28/31). And they were mostly characterized by a lack of blood supply, which was dominated by the Adler blood flow classification of grade 0 51.6% (16/31) and grade I 41.2% (14/31) predominated. The main pathologic subtype of well-differentiated liposarcoma was predominantly hypoechoic in 70.0% (7/10), while dedifferentiated liposarcoma showed a biphasic pattern of hypoechoic in 46.2% (6/13) and hyperechoic in 30.8% (4/13). Conclusion Liposarcoma ultrasound sonograms are characteristic and can be helpful in the ultrasound diagnosis of this disease..