Objective To explore the application value of quantitative parameters of routine ultrasound and contrast-enhanced ultrasound (CEUS) in evaluating the short-term curative effect in patients with cirrhotic portal hypertension (PHT) after transjugular intrahepatic portosystemic shunt (TIPS). Methods A total of 85 patients with PHT undergoing TIPS in Yuncheng Central Hospital were enrolled between January 2019 and January 2023. All underwent routine ultrasound and CEUS examinations at 1d before surgery and 1 month after surgery. The portosystemic pressure gradient (PPG) before and after stent implantation, portal vein diameter (PVD), splenic vein diameter (SVD), superior mesenteric vein diameter (SMVD), portal vein flow velocity (PVV), splenic vein flow velocity (SVV) and superior mesenteric vein velocity (SMVV) before and after surgery, arrival time (AT), time to peak (TTP), rise time (RT), peak intensity (PI) and ascending branch slope (AS) were compared. The relationship between routine ultrasound indexes, CEUS quantitative parameters and PPG in PHT patients after TIPS was analyzed by Pearson correlation analysis. Results PPG after TIPS stent implantation was significantly lower than that before stent implantation [(13.42±2.03) mmHg vs (31.76±6.28) mmHg, P<0.05]. After TIPS, PVD, SVD and SMVD were significantly decreased, while PVV, SVV and SMVV were significantly increased (P<0.05). Pearson correlation analysis showed that PVV, SVV and SMVV were significantly negatively correlated with PPG (P<0.05), while PVD, SVD and SMVD was not correlated with PPG (P>0.05). After TIPS, AT and TTP were significantly shortened, PI and AS were significantly increased (P<0.05). Pearson correlation analysis showed that AT and TTP were significantly positively correlated with PPG, while PI and AS were significantly negatively correlated with it (P<0.05). Conclusion Both routine ultrasound and CEUS quantitative parameters can noninvasively monitor the changes of portal vein pressure in PHT patients before and after TIPS. CEUS quantitative parameters are more effective to monitor and evaluate the short-term curative effect after TIPS.