| 摘要: |
| 目的 探究产前超声量化脑室扩张指导新生儿神经发育评估及预后的价值。方法 选取2021年1月至2022年12月于我院产前检查中胎儿侧脑室扩张的98例孕妇临床资料,纳入扩张组,选取分析同期产前检查中胎儿侧脑室正常的98例孕妇临床资料,纳入正常组。比较两组新生儿产前超声指标[侧脑室宽度、第三室纵径(CD)、丘脑间粘合最大直径(ITAD)]及新生儿神经发育情况[新生儿神经行为(NBNA)评分、盖瑟尔(Gesell)发育量表],经受试者工作特征(ROC)曲线评估产前侧脑室宽度、CD、ITAD对新生儿脑室扩张的诊断效能。根据侧脑室扩张严重程度将扩张组分为轻度、重度组,比较两组新生儿侧脑室宽度、CD、ITAD、NBNA评分及Gesell评分。经pearson相关系数分别评估侧脑室扩张新生儿产前侧脑室宽度、CD、ITAD水平与NBNA评分、Gesell评分的关系。结果 扩张组侧脑室宽度、CD水平高于正常组,ITAD、NBNA评分低于正常组(P均<0.05)；侧脑室宽度、CD、ITAD对脑室扩张具有较高的诊断效能,侧脑室宽度诊断效能最高,其AUC为0.907,敏感度为92.86%,特异度为76.53%(P均<0.05)；重度组侧脑室宽度、CD水平高于中、轻度组,ITAD、NBNA评分、Gesell评分及孕周低于中、轻度组(P均<0.05)；脑室扩张新生儿侧脑室宽度、CD水平与NBNA评分呈负相关,ITAD与NBNA评分呈正相关(P均<0.05)；不同程度侧脑室扩张新生儿在转归方面差异有统计学意义(P均<0.05)。结论 产前超声检查可有效诊断新生儿侧脑室扩张及严重程度,对改善胎儿预后具有重要意义。 |
| 关键词: 脑室扩张 产前超声量化 新生儿 神经发育 评估价值 |
| DOI： |
| 投稿时间：2023-12-28修订日期：2024-01-26 |
| 基金项目: |
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| Value of prenatal ultrasound quantification of ventricular dilatation on guiding neonatal neurodevelopment evaluation and prognosis |
| chengxinyan,hejing,songbohui |
| () |
| Abstract: |
| Objective To explore the value of prenatal ultrasound quantification of ventricular dilation on guiding neonatal neurodevelopment evaluation and prognosis. Methods The clinical data of 98 pregnant women with fetal lateral ventricular dilatation during prenatal examination in our hospital from January 2021 to December 2022 were selected and the women were included in dilatation group. The clinical data of 98 pregnant women with normal fetal lateral ventricle during prenatal examination were selected and the women were enrolled as normal group. Prenatal ultrasound indicators [lateral ventricle width, longitudinal diameter of third ventricle (CD), maximum interthalamic adhesive diameter (ITAD)] and neonatal neurodevelopment status [neonatal neurobehavioral assessment (NBNA) score, Gesell developmental scale] were compared between the two groups of neonates. The diagnostic efficiency of prenatal lateral ventricle width, CD and ITAD on neonatal ventricular dilatation was evaluated by receiver operating characteristic (ROC) curve. According to the severity of lateral ventricular dilatation, the women in dilatation group were divided into mild group and severe group, and the neonatal lateral ventricle width, CD, ITAD, NBNA score and Gesell score were compared. The relationship between prenatal lateral ventricle width, CD, ITAD and NBNA score and Gesell score in neonates with lateral ventricular dilatation was evaluated by pearson correlation coefficient. Results The lateral ventricle width and CD in dilatation group were higher than those in normal group while the ITAD and NBNA score were lower than those in normal group (all P<0.05). Lateral ventricle width, CD and ITAD had high diagnostic efficiency on ventricular dilatation. Lateral ventricle width had the highest diagnostic efficiency, with AUC of 0.907, sensitivity of 92.86% and specificity of 76.53% (all P<0.05). The lateral ventricle width and CD in severe group were higher while the ITAD, NBNA score, Gesell score and gestational age were lower compared with those in moderate group and mild group (all P<0.05). The lateral ventricle width and CD were negatively correlated with NBNA score, while ITAD was positively correlated with NBNA score (all P<0.05). There was a statistical significance in the prognosis aspect among neonates with different degrees of lateral ventricular dilatation (P<0.05). Conclusion Prenatal ultrasound examination can effectively diagnose neonatal lateral ventricular dilatation and its severity, and it is of great significance for improving fetal prognosis. |
| Key words: Ventricular dilatation Prenatal ultrasound quantification Neonates Neurodevelopment Evaluated value |
