| 摘要: |
| 目的：分析超声造影定量参数及血清微RNA-223(miR-223)、白细胞介素6(IL-6)与克罗恩病(CD)炎症活动度的相关性。方法：选取2020年1月～2022年12月在我院诊治的CD患者95例,按照是否处于炎症活动期分为炎症活动期组67例和非炎症活动期组28例,比较两组超声造影定量参数达峰时间(TTP)、上升时间(RT)、峰值强度(PI)及血清miR-223、IL-6水平,并分析超声造影定量参数TTP、RT、PI及血清miR-223、IL-6对CD炎症活动度的预测价值。结果：炎症活动期组TTP、RT与非炎症活动期组比较明显较短(P<0.05),炎症活动期组PI、miR-223、IL-6与非炎症活动期组比较明显较高(P<0.05)。受试者工作特征(ROC)曲线分析显示,TTP、RT、PI、miR-223、IL-6、联合预测CD炎症活动度的曲线下面积(AUC)分别为0.735、0.703、0.796、0.858、0.805、0.992,约登指数分别为0.500、0.434、0.485、0.624、0.507、0.934,在最佳临界值对应的敏感度、特异度分别为：TTP为100.0%、50.0%,RT为97.0%、46.4%,PI为80.6%、67.9%,miR-223为73.1%、89.3%,IL-6为50.7%、100.0%,联合为97.0%、96.4%。结论：超声造影定量参数及血清miR-223、IL-6对CD炎症活动度具有较高的预测价值。 |
| 关键词: 超声造影 定量参数 微RNA-223 白细胞介素6 与克罗恩病 炎症活动度 |
| DOI： |
| 投稿时间：2024-01-17修订日期：2024-01-25 |
| 基金项目: |
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| Correlation analysis of quantitative parameters of contrast-enhanced ultrasound, serum miR-223, IL-6 and inflammatory activity of Crohn |
| chenyuli |
| (The Third People’s Hospital of Chengdu) |
| Abstract: |
| Objective: To analyze the correlation between quantitative parameters of contrast-enhanced ultrasound and serum microRNA-223 (miR-223), interleukin-6 (IL-6) and inflammatory activity of Crohn"s disease(CD). Methods: 95 patients with CD who were diagnosed and treated in our hospital from January 2020 to December 2022 were divided into inflammatory active group (67 cases) and non-inflammatory active group (28 cases) according to whether they were in the inflammatory active phase. The quantitative parameters of contrast-enhanced ultrasound (CEUS) such as peak time (TTP), rise time (RT), peak intensity (PI) and serum miR-223 and IL-6 levels were compared between the two groups, and the quantitative parameters of CEUS such as TTP, RT, PI and serum miR-223 were analyzed The predictive value of IL-6 in inflammatory activity of Crohn"s disease. Results: TTP, RT and non-inflammatory active group were significantly shorter than non-inflammatory active group (P<0.05), PI, miR-223, IL-6 and non-inflammatory active group were significantly higher than non-inflammatory active group (P<0.05). The analysis of subjects" working characteristics (ROC) curve showed that TTP, RT, PI, miR-223, IL-6, and the area under the curve (AUC) of combined prediction of inflammatory activity of CD were 0.735, 0.703, 0.796, 0.858, 0.805, and 0.992, respectively, and the Yoden index was 0.500, 0.434, 0.485, 0.624, 0.507, and 0.934, respectively. The sensitivity and specificity corresponding to the optimal critical value were: TTP was 100.0%, 50.0%, RT was 97.0%, 46.4%, and PI was 80.6%, 67.9%, respectively, MiR-223 was 73.1% and 89.3%, IL-6 was 50.7% and 100.0%, and the combined rate was 97.0% and 96.4%. Conclusion: The quantitative parameters of contrast-enhanced ultrasound and serum miR-223 and IL-6 have high predictive value for the inflammatory activity of CD. |
| Key words: contrast-enhanced ultrasound Quantitative parameters Micro RNA-223 Interleukin 6 Crohn |
