| 摘要: |
| 本研究以病理组织学结果为金标准，探究超声脂肪分数（ultrasound-derived fat fraction，UDFF）评估肥胖人群肝脂肪变性程度的诊断效能。方法 收集2023年4月至12月于山东第一医科大学第一附属医院行超声检查发现脂肪肝并有肝组织病理学结果的肥胖受检者共70人，其中男性15例，女性55例。分析不同病理脂肪分级受检者UDFF测值的一致性、差异性及其与各临床指标和测量深度的相关性，评估UDFF对不同程度肝脂肪变性的诊断效能。结果 S1、S2、S3组UDFF值分别为17.08±7.15%、24.80±5.22%、28.48±5.22%，不同等级脂肪肝UDFF值差异有统计学意义（P＜0.05）。UDFF值与病理脂肪等级显著正相关(r=0.638, P＜0.01)，与测量深度中等相关(r=0.313, P＜0.01)，与体质指数（BMI)、腰围、腹壁厚度弱相关(r=0.236、0.248、0.236, P=0.049、0.038、0.050)，与年龄、空腹血糖、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）无相关性(r=0.138、0.022、-0.027、0.064、0.074、0.076,P均＞0.05)。UDFF诊断S2及以上、S3及以上的曲线下面积（area under curve，AUC）分别为0.86、0.82，灵敏度分别为91.1%、88.0%，特异度分别为72.0%、68.9%，阳性界值分别为20.5%、23.5%。结论 UDFF技术对于评估肥胖人群肝脂肪变性程度具有良好的诊断效能。 |
| 关键词: 超声脂肪分数 代谢相关脂肪性肝病 肝脂肪变性 病理组织学检查 |
| DOI： |
| 投稿时间：2024-01-26修订日期：2024-04-08 |
| 基金项目: |
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| Pathological controlled study of ultrasound-derived fat fraction in assessing the degree of hepatic steatosis in obese population |
| Sun Meng,Luo Fangqiong,Lan Meng,Zhang Xinru,Ma Zhe |
| (Department of Medical Ultrasound,The First Affiliated Hospital of Shandong First Medical University Shandong Provincial Qianfoshan Hospital,Shandong Medicine and Health Key Laboratory of Abdominal Medical Imaging) |
| Abstract: |
| [Abstract] Objective This study investigated the diagnostic efficacy of ultrasound-derived fat fraction (UDFF) in non-invasively assessing the degree of hepatic steatosis in obese people, using pathological and histological findings as the gold standard. Methods A total of 70 obese subjects, including 15 males and 55 females, who underwent ultrasonography and found fatty liver with hepatic histopathological findings in the First Affiliated Hospital of Shandong First Medical University from April to December 2023 were collected. The consistency and variability of UDFF values and their correlation with clinical indicators and measurement depth were analysed to assess the diagnostic efficacy of UDFF for different degrees of hepatic steatosis. Results The UDFF values of groups S1, S2, and S3 were 17.08±7.15%, 24.80±5.22%, and 28.48±5.22%, respectively, and the differences in the UDFF values of different grades of fatty livers were statistically significant (P＜0.05).The UDFF values were significantly and positively correlated with the pathological fat grades (r=0.638, P＜0.01), and moderately with the measurement depth (P＜0.01). depth of measurement moderately (r=0.313, P＜0.01), weakly correlated with BMI, waist circumference, and abdominal wall thickness (r=0.236, 0.248, 0.236, P=0.049, 0.038, 0.050), and did not correlate with age, fasting glucose, triglycerides, total cholesterol, HDL cholesterol, and LDL cholesterol (r= 0.138, 0.022, -0.027, 0.064, 0.074, 0.076, Pall＞0.05).The area under curve (AUC) of UDFF for diagnosis of S2 and above and S3 and above were 0.86, 0.82, with the sensitivity of 91.1%, 88.0%, specificity of 72.0% and 68.9%, and the positive cut-off values were 20.5% and 23.5%, respectively. Conclusion The UDFF technique has good diagnostic efficacy in assessing the degree of hepatic steatosis in obese people. |
| Key words: ultrasonic fat fraction metabolism-related fatty liver disease hepatic steatosis pathohistological examination , |
