Abstract:Objectives: This study aimed to evaluate the accuracy of point shear wave elastography (pswe) and transient elastography (TE) in the staging of liver fibrosis in patients with nonalcoholic fatty liver disease (NAFLD). Methods: Wanfang, CBM, CNKI, PubMed, Web of Science, Embase and Cochrane Library databases up to 1st February 2023 were searched by computer. All subjects were NAFLD patients, and liver hardness was measured by two ultrasonic methods before liver biopsy, excluding those with a history of liver damage, such as chronic hepatitis C, combined with active hepatitis B virus infection, autoimmune liver disease, and suspected drug users and alcoholics. The sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and the area under the working characteristic curve (AUC) of the subjects were analyzed by using a bivariate mixed effect model. Two evaluators independently screened the literature, extracted data, and assessed the risk of bias. Sensitivity analysis was used to explore the heterogeneity between various studies. Meta analysis was performed by Stata 11.0 software. Results: Six pSWE studies comprising a total of 563 patients and 11 TE studies comprising a total of 1897 patients were included. For detection of significant fibrosis, advanced fibrosis and cirrhosis, the summary AUC was 0.85 (95% CI 0.82 to 0.88), 0.95 (95% CI 0.91 to 0.97) and 0.93 (95% CI 0.91 to 0.96) for pSWE, and the summary AUC was 0.83 (95% CI 0.82 to 0.85), 0.90 (95% CI 0.89 to 0.93) and 0.94 (95% CI 0.91 to 0.96) for TE, respectively. The proportion of failure measurement was higher with TE using an M probe compared with pSWE. Conclusion: pSWE and TE, can provide noninvasive and accurate staging of NAFLD liver fibrosis, especially in advanced liver fibrosis and cirrhosis, and have a good application prospect.