| 摘要: |
| 目的 对比研究低海拔急进高海拔试验人群(下称试验人群)与高原原住居民ONS的特点及差异,研究试验人群ONSD随高原居住时间的变化规律。方法 54名试验人群,急进至海拔3500m处高原居住不少于6个月时间。试验人群初到高原时、居住3月及6月时超声测定ONSD。原住居民137名获取一次ONSD。收集两组人群性别、身高、体重、民族、吸烟史、基础疾病及是否近视眼等数据。结果 试验人群初到高原时女性LONSD为4.846±0.073 mm,RONSD为4.838±0.068 mm；男性LONSD为5.038±0.038 mm,RONSD为5.055±0.039mm。原住居民女性LONSD为5.144±0.031 mm,RONSD为5.183±0.029mm；男性LONSD为5.326±0.037mm,RONSD为5.360±0.047mm。两组人群ONSD存在性别差异,男性大于女性,比较具有统计学差异(p<0.05)。原住居民ONSD大于试验人群ONSD,比较有显著统计学差异(p<0.01)。在高原居住3月时女性LONSD为4.869±0.067mm,RONSD为4.869±0.054mm；男性LONSD为5.080±0.036mm,RONSD为5.068±0.033mm；居住6月时女性LONSD为4.954±0.057mm,RONSD为4.977±0.073mm；男性LONSD为5.180±0.042mm,RONSD为5.250±0.045mm。女性ONSD均值随高原居住时间增加而变宽,但与初到高原时比较未见统计学差异(p>0.05)。男性ONSD均值随高原居住时间增加而变宽,6月时ONSD与初到高原时比较有统计学差异(p<0.05)。结论 1.ONSD存在性别差异；2.高原原住居民ONSD大于试验人群ONSD；3. 试验人群ONSD宽度随高原居住时间增加,且高原对男性ONS影响较女性大。 |
| 关键词: 视神经鞘 高原 颅内压 |
| DOI： |
| 投稿时间：2024-04-03修订日期：2024-05-09 |
| 基金项目:基础加强计划重点基础研究项目 |
|
| A comparative study on the changes of optic nerve sheath in rapidly advancing high-altitude trial populations and their comparison with original residents |
| Zhang Yunyun,Yang Deng,Li Xinshun,Ma Xiaoting,Zhang Jianbo |
| () |
| Abstract: |
| Objective To study the characteristics and differences of ONSD between the low altitude rapid advance high-altitude trial populations(TPs) and the plateau original residents(ORTs), and investigate the variation pattern of ONSD in the trial populations with the plateau residential time. Methods 54 people from low altitude to high altitude lived in the plateau with an altitude of about 3500m for at least 6 months. ONSD was determined by ultrasound when the TPs first arrived at the plateau and lived in 3 and 6 months. 137 ORTs get ONSD once. Information on gender, height, weight, ethnicity, smoking history, underlying diseases, and nearsightedness were collected. Results When the TPs first arrived at the plateau, the female LONSD was 4.846 ± 0.073 mm, and the RONSD was 4.838 ± 0.068 mm; Male LONSD is 5.038 ± 0.038 mm, and RONSD is 5.055 ± 0.039 mm; The female LONSD among ORTs is 5.144 ± 0.031 mm, and the RONSD is 5.183 ± 0.029 mm; The male LONSD is 5.326±0.037mm, and the RONSD is 5.360 ± 0.047mm. There is a gender difference in ONSD between ORTs and TPs, with male ONSD being greater than female ONSD, indicating a statistically significant difference (p<0.05); There was a significant statistical difference (p<0.01) in the ONSD of ORTs compared to the TPs. When living in the plateau for 3 months, the female LONSD was 4.869 ± 0.067mm, and the RONSD was 4.869 ± 0.054mm; Male LONSD is 5.080 ± 0.036mm, and RONSD is 5.068 ± 0.033mm; When living in the plateau for 6 months, the female LONSD was 4.954 ± 0.057mm, and the RONSD was 4.977 ± 0.073mm; The male LONSD is 5.180 ± 0.042mm, and the RONSD is 5.250 ± 0.045mm. Women showed that the mean ONSD increased with the increase of living time at high altitude, but there was no statistically significant difference in ONSD between June and when they first arrived at high altitude (p>0.05). Men also showed that the mean ONSD increased with the increase of living time at high altitude, and there was a statistical difference (p<0.05) between ONSD in June and when they first arrived at high altitude. Conclusion 1. The width of ONSD is different between male and female. 2. The ONSD of ORTs is greater than that of TPs; 3. The ONSD width of the TPs increases with the plateau residence time, and the influence on males is greater than that on females. |
| Key words: Optic Nerve Sheath Plateau intracranial pressure |
