剪切波频散成像在肝脏疾病诊断中的应用进展
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1.兰州市第三人们医院;2.上海市瑞金医院门诊三楼超声医学科

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Application of ultrasonic shear wave dispersion imaging in the diagnosis of liver diseases
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    摘要:

    超声剪切波弹性成像(SWE)被广泛认为是肝脏硬度定量评估和疾病分期的首选影像成像方法之一。但其技术的实现是基于将肝实质视为理想化的均质体弹性模型之上,SWE在用于量化肝脏弹性的算法中忽略了组织黏度特性,在评估炎症或脂肪变性等慢肝患者时存在有一定局限性。剪切波频散成像(SWD)可以获得一个与黏度直接相关的参数:实际的分散定量剪切波频散成像(SWD)可以获得一个与黏度直接相关的参数:实际的分散定量,分散定量参数可以用来评估肝组织黏度与相关的剪切波速度分散情况。既往研究表明,在预测肝纤维化程度方面,剪切波速度比频散斜率更有用,但在预测坏死性炎症程度和脂肪沉积方面,频散斜率比剪切波速度更有诊断价值。因此,我们可以通过剪切波频散斜率的测量来更好地描述肝脏的力学性质。我们可以用频散斜率来预测坏死性炎症的程度、检测肝移植后的同种异体移植物损伤以及良恶性肝脏灶性病的鉴别诊断,在肝纤维化的分期中,也可以用频散斜率来协助排除显著肝纤维化和诊断肝硬化。相信在未来SWD可能会成为用来量化和早期筛查肝脏弥漫性病变以及肝脏局灶性病变的新的成像方法。

    Abstract:

    Ultrasound shear wave elastography (SWE) is widely regarded as one of the preferred imaging methods for quantitative assessment of liver hardness and disease staging. However, the implementation of its technology is based on an idealized homogeneous elastic model that considers liver parenchyma. SWE ignores tissue viscosity characteristics in algorithms used to quantify liver elasticity, which has certain limitations in evaluating patients with chronic liver disease such as inflammation or steatosis. Shear wave dispersion imaging (SWD) can obtain a parameter directly related to viscosity: actual dispersion quantification shear wave dispersion imaging (SWD) can obtain a parameter directly related to viscosity: actual dispersion quantification, dispersion quantification parameters can be used to evaluate liver tissue viscosity and related shear wave velocity dispersion. Previous studies have shown that shear wave velocity is more useful than dispersion slope in predicting the degree of liver fibrosis, but dispersion slope is more diagnostic than shear wave velocity in predicting the degree of necrotizing inflammation and fat deposition. Therefore, we can better describe the mechanical properties of the liver by measuring the slope of shear wave dispersion. We can use dispersion slope to predict the degree of necrotizing inflammation, detect allograft damage after liver transplantation, and differentiate between benign and malignant liver focal diseases. In the staging of liver fibrosis, dispersion slope can also be used to assist in excluding significant liver fibrosis and diagnosing cirrhosis. I believe that in the future, SWD may become the preferred imaging method for quantifying and staging diffuse and focal liver lesions.

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王婷婷,任新平.剪切波频散成像在肝脏疾病诊断中的应用进展[J].临床超声医学杂志,2025,27(2):170-173

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  • 收稿日期:2024-05-15
  • 最后修改日期:2024-05-27
  • 录用日期:2024-06-14
  • 在线发布日期: 2025-03-04
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