| 摘要: |
| 目的 探讨超声衰减系数(AC)定量诊断非酒精性脂肪肝病(NAFLD)的临床应用价值。 方法 随机选取2022年2月至2024年4月在我院就诊并接受腹部CT检查和抽血检查的120例受试对象,根据肝/脾 CT 比值(LSR)判断脂肪肝严重程度进行分级,N0、N1、N2、N3分别对应无脂肪肝组、轻度、中度、重度,各组分别纳入受试者30例。同时进行声衰减成像(ATI)技术测定AC值,获得不同程度脂肪肝的最佳界值。分析AC与LSR、体重指数(BMI)、甘油三酯(TG)的相关性。 结果 各组间AC、LSR、BMI、TG均存在统计学差异(P<0.05),ROC曲线分析得出,≥N1、≥N2、≥N3的AC界值分别是0.73、0.80、0.88 dB/cm/MHz,其对应的灵敏度分别为83.33%、90%、96.67%；对应的特异度为80%、86.67%、96.67%。AC值与LSR、BMI、TG均成正相关。 结论 通过ATI技术无创评估非酒精性脂肪肝的严重程度,AC诊断范围为：N0＜0.73 dB/cm/MHz；0.73 dB/cm/MHz≤N1＜0.80 dB/cm/MHz；0.80 dB/cm/MHz≤N2＜0.88 dB/cm/MHz；N3≥0.88 dB/cm/MHz,对患者的后期随访和门诊检测具有非常重要的指导意义。 |
| 关键词: 声衰减成像 超声衰减系数 非酒精性脂肪肝病 |
| DOI： |
| 投稿时间：2024-05-21修订日期：2024-09-09 |
| 基金项目: |
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| The clinical value of sound attenuation imaging to quantitatively assess the degree of non-alcoholic fatty liver disease |
| Zhou Xueting,Zhang Guangjun,He Chaohong,Su Xiaoxiao,Tan Huimin |
| (Ultrasound Diagnostic Department,Shunde Hospital of Southern Medical University) |
| Abstract: |
| Objective Explore the value of clinical application of ultrasound attenuation coefficient (AC) in the quantitative diagnosis of non-alcoholic fatty liver disease (NAFLD). Methods Select a total of 120 subjects who had received abdominal CT examination and blood sampling in our hospital from Feb 2022 to Apr 2024 at random, and grade the severity of fatty liver according to the liver/spleen CT ratio (LSR), and relate N0, N1, N2, and N3 to the non-fatty liver, mild, moderate, and severe groups, respectively, each group including 30 subjects. Adopt acoustic attenuation imaging (ATI) to examine the AC value, meanwhile measure the AC value by sound attenuation imaging (ATI) technology to obtain the optimal cut-off values of different degrees of fatty liver.Analyze the correlation between AC and LSR, body mass index (BMI) and triglyceride (TG). Results There were statistically significant differences in AC, LSR, BMI, and TG among the groups (P<0.05), and the ROC curve analysis showed that the AC cut-off values of ≥ N1, ≥N2, and ≥N3 were 0.73, 0.80, and 0.88 dB/cm/MHz, respectively, and the corresponding sensitivities were 83.33%, 90%, and 96.67%, respectively. The corresponding specificities were 80%, 86.67% and 96.67%. AC values were positively correlated with LSR, BMI and TG. Conclusion The severity of non-alcoholic fatty liver disease was assessed non-invasively by ATI technique, and the hierarchies of diagnosis of AC was: N0<0.73 dB/cm/MHz; 0.73 dB/cm/MHz≤N1＜0.80 dB/cm/MHz；0.80 dB/cm/MHz≤N2＜0.88 dB/cm/MHz；N3≥0.88 dB/cm/MHz. It is intensively significant in guiding the follow-up and outpatient testing of patients. |
| Key words: Acoustic attenuation imaging technology, Ultrasonic attenuation coefficient, NAFLD |
