二维超声、剪切波弹性成像联合肾功能检查诊断2型糖尿病合并肌少症的临床价值
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1.宿迁市钟吾医院超声科;2.宿迁市钟吾医院内分泌科;3.宿迁市钟吾医院老年科

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宿迁市科技计划资助项目


Correlation between gastrocnemius and diabetic nephropathy complicated with sarcopenia evaluated by conventional ultrasound combined with shear wave elastography
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Department of Ultrasound,Zhongwu Hospital of Suqian,Nanjing Suqian

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The Suqqian Sci&Tech Program

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    摘要:

    目的 探讨常规超声联合剪切波弹性成像(shear wave elastography, SWE)评价腓肠肌与2型糖尿病(type 2 diabetes mellitus,T2DM)合并肌少症的相关性。方法 选择2020年1月~2023年1月在我院就诊的112例T2DM患者。根据亚洲肌肉减少症工作组(AWGS)制定的肌少症的诊断标准将患者分为T2DM组和T2DM合并肌少症组。采用常规超声测量右侧腓肠肌内侧头肌肉厚度、羽状角及肌束长度。采用SWE测量腓肠肌杨氏模量和剪切波速(shear wave velocity, SWV)。单因素和多因素二元Logistic回归分析临床和超声特征与T2DM合并肌少症的相关性。结果 单因素分析结果显示临床特征中,T2DM合并肌少症组患者糖尿病病程长于T2DM组,糖化血红蛋白含量高于T2DM组;而肾功能指标中,T2DM合并肌少症组患者肌酐、尿蛋白增高,eGFR降低,差异均具有统计学意义(P均<0.05)。超声测量腓肠肌结果显示,T2DM合并肌少症组患者腓肠肌厚度、羽状角、肌束长度、杨氏模量和SWV均小于T2DM组,差异具有统计学意义(P均<0.05)。多因素二分类Logistic回归分析结果显示肌酐水平(OR = 1.434;95 CI OR:1.023~2.011,P = 0.036)、腓肠肌肌束长度(OR:0.917;95 CI OR:0.857~0.981,P = 0.0126)、腓肠肌肌肉厚度(OR = 0.794;95 CI OR:0.668~0.944,P = 0.009)、杨氏模量(OR = 0.678;95 CI OR:0.530~0.868,P = 0.002)、以及SWV(OR = 0.484;95 CI OR:0.299~0.785,P = 0.003)与T2DM合并肌肉减少症独立相关,其ROC曲线下面积为0.936(95%CI:0.890~0.981),敏感性为82.95%,特异性为95.83%。结论 常规超声和SWE测量小腿腓肠肌杨氏模量和SWV值降低、厚度和肌束长度减小,同时伴有肾功能下降,可能提示T2DM患者合并肌少症。常规超声联合SWE与肾功能水平有助于临床医生早期识别T2DM合并肌少症,并为干预和改善患者预后提供辅助信息。

    Abstract:

    Objective To evaluate the relationship between gastrocnemius and type 2 diabetes mellitus (T2DM) complicated with sarcopenia by conventional ultrasound and shear wave elastography (SWE). Methods 112 patients with T2DM were selected from our hospital from January 2020 to January 2023. According to the diagnostic criteria for sarcopenia by the Asian Working Group for Sarcopenia (AWGS), the patients were divided into T2DM group and T2DM complicated with sarcopenia group. The muscle thickness, feathery angle and muscle bundle length of the medial head of the right gastrocnemius were measured by conventional ultrasound. Young"s modulus and shear wave velocity (SWV) of gastrocnemius muscle was measured by SWE. Univariate and multivariate binary Logistic regression were used to analyze the correlation between clinical and ultrasonic features for T2DM complicated with sarcopenia. Results Univariate analysis showed that the duration of diabetes in T2DM patients complicated with sarcopenia was longer than that in T2DM group, and the content of glycosylated hemoglobin was higher than that in T2DM group. Among renal function parameters, more patients with increased creatinine and urinary protein, and decreased eGFR in T2DM complicated with sarcopenia group, with statistical significance (P < 0.05). The results of ultrasonic measurements of gastrocnemius muscle showed that the thickness, feathery angle, muscle bundle length, Young"s modulus and SWV in T2DM complicated with sarcopenia group were lower than those in T2DM group, and the differences were statistically significant (P < 0.05). Multivariate binary Logistic regression analysis showed that creatinine level (OR = 1.434; 95 CI OR: 1.023~2.011, P = 0.036), muscle bundle length of gastrocnemius (OR: 0.917; 95 CI OR: 0.857~0.981, P = 0.0126), muscle thickness of gastrocnemius (OR = 0.794; 95 CI OR: 0.668~0.944, P = 0.009), Young"s modulus (OR = 0.678; 95 CI OR: 0.530~0.868, P = 0.002) and SWV of gastrocnemius (OR = 0.484; 95 CI OR: 0.299-0.785, P = 0.003) was independently correlated with T2DM complicated with sarcopenia. The area under ROC curve was 0.936 (95%CI: 0.890-0.981), the sensitivity was 82.95%, and the specificity was 95.83%. Conclusion The decrease of Young"s modulus and SWV value, thickness and shorter bundle length of gastrocnemius measured by conventional ultrasound and SWE, and decreased renal function may indicate that T2DM patients are complicated with sarcopenia. Conventional ultrasound combined with SWE and decreased renal function can help clinicians identify T2DM with sarcopenia at an early stage, and provide auxiliary information for intervention and improvement of patient prognosis.

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单思维,周付成,林媛,许雪.二维超声、剪切波弹性成像联合肾功能检查诊断2型糖尿病合并肌少症的临床价值[J].临床超声医学杂志,2025,27(1):70-75

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  • 收稿日期:2024-05-21
  • 最后修改日期:2024-12-08
  • 录用日期:2024-10-11
  • 在线发布日期: 2025-02-07
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