ABSTRACT Objective The purpose of this study is to explore the application effect and significance of the integrated medical and nursing management model in contrast-enhanced ultrasound (CEUS) examination. Method Clinical data of patients who underwent intravenous injection of sulfur hexafluoride microbubbles for CEUS examination in our hospital from January 2019 to December 2023 were collected through hospital image archiving and communication systems for retrospective analysis. Patients were divided into a study group (January 2022 to December 2023) and a control group (January 2019 to December 2020) based on whether integrated medical and nursing management was implemented. The waiting time, incidence of adverse reactions, and patient satisfaction of the two groups were compared.Results The results included a total of 20674 study patients and 18942 control group patients, with similar age and proportion of outpatient and inpatient patients in both groups. During the same time period and with an increase in personnel and consultation rooms, the research group achieved a 9.1% improvement in work efficiency compared to the control group. Compared with the control group, the waiting time of patients in the study group was significantly shortened (p<0.001), patient satisfaction was significantly improved (p<0.001), and the incidence of adverse reactions was significantly reduced (0.069% vs 0.024%, p=0.038). . All patients who experienced adverse reactions were actively treated and recovered, and were discharged from the hospital. Conclusion Implementing integrated medical and nursing management in CEUS examinations can effectively increase work efficiency, shorten patient waiting time, reduce adverse reactions, and improve patient satisfaction.