应用超微细血流成像技术评估妊娠期高血压疾病胎盘血流灌注及对妊娠结局的预测价值
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云南省昆明市妇幼保健院

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昆明市卫生健康委员会科研基金 2022-SW(后备)-93


Ultrafine flow imaging was used to evaluate placental flow perfusion of hypertensive disorders in pregnancy and its predictive value for pregnancy outcome
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    摘要:

    【】目的 探讨超声微血管成像技术(SMI)评估妊娠期高血压疾病(HDCP)患者胎盘灌注水平及预测不良妊娠结局的价值。方法? 选取昆明市妇幼保健院103例确诊HDCP孕妇作为HDCP组,同期妊娠且血压正常的孕妇105例作为对照组,对两组进行SMI检查,并对比胎盘血流灌注参数及不良妊娠结局发生率,按照病情程度将HDCP组患者分为单纯高血压组、轻度子痫前期组、重度子痫前期组进行分层对比,采用受试者工作特征曲线(ROC)分析各项灌注指标预测不良妊娠结局的价值。结果? HDCP组的子宫动脉PI、S/D、RI测定值均高于对照组,HDCP组的胎盘VI值低于对照组,上述各项指标经统计学分析差异显著(P<0.05); HDCP组的脐动脉PI、S/D、RI测定值均高于对照组,上述各项指标经统计学分析差异显著(P<0.05); 单纯妊娠期高血压患者、轻度子痫前期患者、重度子痫前期患者的子宫动脉PI、S/D、RI测定值逐渐升高,胎盘VI值逐渐降低,各组之间两两比较上述各项指标经统计学分析差异显著(P<0.05);单纯妊娠期高血压患者、轻度子痫前期患者、重度子痫前期患者的脐动脉PI、S/D、RI测定值逐渐升高,各组之间两两比较上述各项指标经统计学分析差异显著(P<0.05);HDCP组的早产、剖宫产、新生儿窒息、胎儿生长受限、胎儿窘迫发生率均高于对照组,上述各项指标经统计学分析差异显著(P<0.05)。子宫动脉PI、S/D、RI、胎盘VI值及四者联合应用预测HDCP孕妇出现不良妊娠结局的ROC曲线下面积AUC值分别为0.654、0.576、0.671、0.762、0.884;脐动脉PI、S/D、RI、胎盘VI值及四者联合应用预测HDCP孕妇出现不良妊娠结局的ROC曲线下面积AUC值分别为0.700、0.712、0.779、0.762、0930。结论 通过SMI技术评估HDCP患者子宫动脉、脐动脉血流参数及胎盘灌注水平,可有效评估妊娠期高血压病情,并且对HDCP孕妇不良妊娠结局具有较高的预测价值。

    Abstract:

    【】Objective? Exploring the value of ultrasound microvascular imaging (SMI) in evaluating placental perfusion levels and predicting adverse pregnancy outcomes in patients with gestational hypertension disorder (HDCP). Methods? A total of 103 pregnant women diagnosed with HDCP in Kunming Maternal and Child Health Hospital were selected as the HDCP group, and 105 pregnant women with normal blood pressure during the same period were selected as the control group. SMI examination was performed between the two groups, and placental blood perfusion parameters and the incidence of adverse pregnancy outcomes were compared. Patients in HDCP group were divided into simple hypertension group, mild preeclampsia group and severe preeclampsia group according to the severity of the disease, and the value of perfusion indexes in predicting adverse pregnancy outcomes was analyzed by receiver operating characteristic curve (ROC).? Results The values of uterine artery PI, S/D and RI in the HDCP group were higher than those in the control group, and the values of placental VI in the HDCP group were lower than those in the control group, and the above indexes were statistically significant (P<0.05). The PI, S/D and RI values of umbilical artery in HDCP group were higher than those in control group, and the differences were statistically significant (P<0.05). The values of uterine artery PI, S/D and RI in patients with simple pregnancy hypertension, mild preeclampsia and severe preeclampsia gradually increased, while the values of placenta VI gradually decreased. Pin-two comparison of the above indexes among all groups showed significant differences (P<0.05). The PI, S/D and RI values of umbilical artery were gradually increased in patients with simple pregnancy hypertension, mild preeclampsia and severe preeclampsia, and the above indexes were statistically significant among all groups (P<0.05). The incidence of preterm delivery, cesarean section, neonatal asphyxia, fetal growth restriction and fetal distress in HDCP group were higher than those in control group, and the above indexes were statistically significant (P<0.05). The area AUC values of uterine artery PI, S/D, RI, placenta VI and the combined application of the four to predict adverse pregnancy outcomes in HDCP pregnant women were 0.654, 0.576, 0.671, 0.762 and 0.884, respectively. The area AUC values of umbilical artery PI, S/D, RI, placenta VI and the combination of the four to predict adverse pregnancy outcomes in HDCP pregnant women were 0.700, 0.712, 0.779, 0.762 and 0930, respectively. Conclusion Evaluating uterine artery and umbilical artery blood flow parameters and placental perfusion levels in HDCP patients through SMI technology can effectively assess the condition of gestational hypertension and has high predictive value for adverse pregnancy outcomes in HDCP pregnant women.

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黄仙.应用超微细血流成像技术评估妊娠期高血压疾病胎盘血流灌注及对妊娠结局的预测价值[J].临床超声医学杂志,2025,27(3):

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  • 收稿日期:2024-07-07
  • 最后修改日期:2024-08-13
  • 录用日期:2024-08-27
  • 在线发布日期: 2025-04-02
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